Inhibition of Mn~2+_2-Arginase by Borate Leads to the Design of a Transition State Analogue Inhibitor, 2(S)-Amino-6-boronohexanoic Acid

摘要

We propose that the high affinity of 6 toward arginase arises from the fact that in the hydrated form, it is the closest structural analogue of the tetrahedral intermediate (and its flanking transition states) generated to date. Future work will involve the X-ray crystal structure determi- nation of the complex between arginase and 6 in order to verify the proposed binding mode outlined in Figure.