Immunologic and Virologic Events in Early HIV Infection Predict Subsequent Rate of Progression

摘要

Background.Variability in human immunodeficiency virus (HIV) disease progression cannot be fully predicted by CD4+ T cell counts or viral load (VL). Because central memory T(T_CM)cells play a critical role in the pathogenesis of simian immunodeficiency virus disease, we hypothesized that quantifying these cells in early HIV infection could provide prognostic information.