Precision of cerebral oxygenation and hemoglobin concentration measurements in neonates measured by near-infrared spectroscopy

摘要

Abstract. Background and aim: One source of error with near-infrared spectroscopy (NIRS) is the assumptionnthat the measured tissue is optically homogeneous. This is not always the case. Our aim is to assess the impactnof tissue homogeneity (TH) on the precision of NIRS measurements in neonates. Methods: On 36 term and 27npreterm neonates at least five 1-min measurements are performed on each subject using the OxiplexTS. Thensensor position is slightly changed before each measurement while assessing TH. The precision for cerebral tissuenoxygenation saturation (StO2) and total hemoglobin concentration (tHb) are calculated by repeated measuresnanalysis of variance. Results: The mean StO2 is not significantly different between term and preterm infants. Thenmean tHb is significantly lower in preterm infants (p < 0.01). With increasing TH, the precision of StO2 increasenfrom 5.6 to 4.6% for preterm and from 11.0 to 2.0% for term infants; the precision of tHb increases from 10.1nto 7.5μM for preterm and from 16.4 to 3.5μM for term infants. The precision for StO2 is higher in term than innpreterm infants. The precision for tHb shows no significant difference between the two groups. Conclusions: Thenprecision of NIRS measurements correlates with tissue homogeneity. C u00022011 Society of Photo-Optical Instrumentation Engineersn(SPIE). [DOI: 10.1117/1.3570303]