Synthesis of Polyfunctionalized Pyrroles by a PPh_3-Promoted Condensation Reaction between Ammonium Acetate, Dialkyl Acetylenedicarboxylate and Arylglyoxals

摘要

A simple and efficient synthesis of some polyfunctionalized pyrrole derivatives by a triphenylphosphine-promoted condensation reaction between dialkyl acetylenedicarboxylates, arylglyoxals, and ammonium acetate is described. This present method carries several advantages, such as good yields, a simple procedure, non-hazardous reaction conditions and starting from easily accessible substrates.