Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-AdditionReactions: Synthesis of 2367-Tetrahydro-1H-pyrrolo32-cpyridin-4(5H)-ones

摘要

An efficient tandem intermolecular one-pot aldol condensation/aza-addition reaction of 2-methyl-3-carbamoylpyrroles and aldehydes was developed for the synthesis of 2,3,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones. The reaction proceeded using only 3.0 equiv of ammonium acetate promoter in green solvent poly(ethylene glycol)-400 at 100 °C to afford a series of pyrrolo[3,2-c]pyridinone derivatives in good to excellent yields.