An efficient synthesis of pentasubstituted pyrroles: one-pot four-component reaction of arylamine, acetylenedicarboxylate, arylglyoxal, and symmetrical 1,3-dicarbonyl compounds

摘要

An efficient and catalyst-free for the synthesis of dialkyl 5-(aryl)-4-(1,3-dicarbonyl)-1-(aryl)-1H-pyrrole-2,3-dicarboxylate via a novel one-pot four-component reaction of arylamine, acetylenedicarboxylate, arylglyoxal, and 1,3-dicarbonyl compounds in ethanol is reported. All the products were obtained in excellent yields and their structures were established from their spectroscopic data.