Inflammatory Pain Pharmacological Treatment Strategy with Prostaglandin E Receptor 4 Antagonist

摘要

Prostaglandin E2 (PGE2) has been associated with inflammatory conditions and is considered a proinflammatory mediator in the mechanism of inflammation and pain hypersensitivity. PGE2 is a major mediator of peripheral inflammation and processing of pain signals. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly applied as the pain reliever attempts to inhibit COX-1 and/or COX-2 to lessen occurrence of PGE2 and other prostanoids. However, usage of COX inhibitors has been reported to have side effects that include gastrointestinal and renal toxicity, and certain types of COX-2 inhibitors are associated with an increased cardiovascular risk among patients. In view of this, an alternative strategy by target PGE2 production with inhibitors of PGE synthases or blockade of PGE2 receptors was suggested to develop analgesics that enable prevention of potential cardiovascular and renal side-effects.