Bosentan, an endothelin receptor antagonist, ameliorates collagen-induced arthritis: the role of TNF-α in the induction of endothelin system genes

Paula B. Donate; Thiago M. Cunha; Waldiceu A. Verri Jr; Cristina M. Junta; Flavia O. Lima; Silvio M. Vieira; Rafael S. Peres; Karina F. Bombonato-Prado; Paulo Louzada Jr; Sergio H. Ferreira; Eduardo A. Donadi; Geraldo A. S. Passos; Fernando Q. Cunha

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Bosentan, an endothelin receptor antagonist, ameliorates collagen-induced arthritis: the role of TNF-α in the induction of endothelin system genes

机译：内皮素受体拮抗剂波生坦可改善胶原蛋白诱发的关节炎：TNF-α在诱导内皮素系统基因中的作用

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Endothelins (ETs) are involved in several inflammatory events. The present study investigated the efficacy of bosentan, a dual ETA/ETB receptor antagonist, in collagen-induced arthritis (CIA) in mice.

机译：内皮素（ETs）参与几种炎症事件。本研究调查了双重ETA / ETB受体拮抗剂波生坦在小鼠胶原诱导的关节炎（CIA）中的功效。

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来源
《Inflammation Research》 |2012年第4期|p.337-348|共12页
作者
Paula B. Donate; Thiago M. Cunha; Waldiceu A. Verri Jr; Cristina M. Junta; Flavia O. Lima; Silvio M. Vieira; Rafael S. Peres; Karina F. Bombonato-Prado; Paulo Louzada Jr; Sergio H. Ferreira; Eduardo A. Donadi; Geraldo A. S. Passos; Fernando Q. Cunha;
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作者单位

Post Graduation Program in Basic and Applied Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Avenue Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil;

Post Graduation Program in Basic and Applied Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Avenue Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil;

Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Avenue Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil;

Department of Genetics, School of Medicine of Ribeirão Preto, University of São Paulo, Avenue Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil;

Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Avenue Bandeirantes, 3900,;

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正文语种 eng
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关键词
Rheumatoid arthritis; Collagen-induced arthritis; Bosentan; Inflammation; Microarray; Endothelins;

机译：类风湿关节炎;胶原性关节炎;波生坦;炎症;芯片;内皮素;

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1. Bosentan, an endothelin receptor antagonist, ameliorates collagen-induced arthritis: the role of TNF-α in the induction of endothelin system genes. [J] . Paula B Donate, Thiago M Cunha, Waldiceu A Verri, Inflammation research: Official journal of the European Histamine Research Society . 2012,第4期

机译：内皮素受体拮抗剂波生坦可改善胶原蛋白诱发的关节炎：TNF-α在诱导内皮素系统基因中的作用。
2. The endothelin receptor antagonist ameliorates the hypertensive phenotypes of transgenic hypertensive mice with renin-angiotensin genes and discloses roles of organ specific activation of endothelin system in transgenic mice [J] . Maki S., Miyauchi T., Kakinuma Y., Life sciences . 2004,第9期

机译：内皮素受体拮抗剂改善了具有肾素-血管紧张素基因的转基因高血压小鼠的高血压表型，并揭示了器官特异性激活内皮素系统在转基因小鼠中的作用
3. Role of endothelin in the circulatory changes associated with small bowel strangulation obstruction in pigs: effects of the endothelin receptor antagonist bosentan. [J] . Fevang J, Ovrebo K, Myking O, Journal of Surgical Research: Clinical and Laboratory Investigation . 2001,第2期

机译：内皮素在猪小肠绞窄阻塞相关循环变化中的作用：内皮素受体拮抗剂波生坦的作用。
4. Role of Angiotensin II and Endothelin-1 Receptors in Aging-Related Functional Changes in Rat Cardiovascular System [C] . AKIRA ISHIHATA, YUMI KATANO, University of Aarhus, International Association of Biomedical Gerontology International . 2006

机译：血管紧张素II和内皮素-1受体在大鼠心血管系统中衰老相关功能变化中的作用
5. Endothelin and endothelin receptors in the fish gill. [D] . Hyndman, Kelly Anne. 2008

机译：鱼g中的内皮素和内皮素受体。
6. A non-selective endothelin receptor antagonist bosentan modulates kinetics of bone marrow-derived cells in ameliorating pulmonary hypertension in mice [O] . Taichi Kato, Yoshihide Mitani, Masahiro Masuya, 2020

机译：非选择性内皮素受体拮抗剂Bosentan调节骨髓衍生细胞的动力学在微小的小鼠中的改善肺动脉高压
7. Bosentan, an endothelin receptor antagonist, ameliorates collagen-induced arthritis: the role of TNF-alpha in the induction of endothelin system genes [O] . Donate Paula B., Cunha Thiago M., Verri Waldiceu A. Jr., 2012

机译：内皮素受体拮抗剂波生坦可改善胶原蛋白诱发的关节炎：TNF-α在诱导内皮素系统基因中的作用

Bosentan, an endothelin receptor antagonist, ameliorates collagen-induced arthritis: the role of TNF-α in the induction of endothelin system genes

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