EFFECTS OF MAGNESIUM SULPHATE ON THE OXIDATIVE STRESS, BIOCHEMICAL AND HEMATOLOGICAL PARAMETERS IN PREGNANT RATS WITH L-NAME INDUCED PREECLAMPSIA

摘要

The aim of this study was to investigate the effects of magnesium sulphate (MgSO_4) on some biochemical and hematological parameters, lipid peroxidation, and antioxi-dant enzymes in pregnant rat model of preeclampsia induced by Lw-nitro-L-arginine methyl ester (L-NAME). Thirty two pregnant Sprague-Dawley rats were divided into 4 equal groups as control, L-NAME (50 mg/kg bw/day), MgSO_4 (600 mg/kg bw/day) or L-NAME + MgSO_4 (1-4) given groups on the 11th day of the pregnancy in their drinking water. The increased blood pressure (BP) was detected on the 12th and 19th days of pregnancy. Blood samples were collected on the 19th day to determine blood oxidative status, some biochemical and hematological parameters. L-NAME decreased erythrocyte superoxide dismutase activity, plasma total protein level and increased erythrocyte catalase and glutathion peroxidase activities, BP, plasma malondialdehyde, cholesterol and triglyceride levels, alkaline phophatase activity and white blood cell counts compared to control group. While MgSO_4 decreased aspartate amino transferase and alanine amino transferase activities and calcium level, it increased magnesium level compared to control group. Increased BP, plasma cholesterol levels, erythrocyte catalase and glutathione peroxidase activities by L-NAME were decreased by the addition of MgSO_4. In conclusion, MgSO_4 (600 mg/kg bw/day) may be beneficial in the treatment of preeclampsia by increasing usage of antioxidant enzymes