A semi-supervised fuzzy GrowCut algorithm to segment and classify regions of interest of mammographic images

摘要

According to the World Health Organization, breast cancer is the most common form of cancer in women. It is the second leading cause of death among women round the world, becoming the most fatal form of cancer. Despite the existence of several imaging techniques useful to aid at the diagnosis of breast cancer, x-ray mammography is still the most used and effective imaging technology. Consequently, mammographic image segmentation is a fundamental task to support image analysis and diagnosis, taking into account shape analysis of mammary lesions and their borders. However, mammogram segmentation is a very hard process, once it is highly dependent on the types of mammary tissues. The GrowCut algorithm is a relatively new method to perform general image segmentation based on the selection of just a few points inside and outside the region of interest, reaching good results at difficult segmentation cases when these points are correctly selected. In this work we present a new semi-supervised segmentation algorithm based on the modification of the GrowCut algorithm to perform automatic mammographic image segmentation once a region of interest is selected by a specialist. In our proposal, we used fuzzy Gaussian membership functions to modify the evolution rule of the original GrowCut algorithm, in order to estimate the uncertainty of a pixel being object or background. The main impact of the proposed method is the significant reduction of expert effort in the initialization of seed points of GrowCut to perform accurate segmentation, once it removes the need of selection of background seeds. Furthermore, the proposed method is robust to wrong seed positioning and can be extended to other seed based techniques. These characteristics have impact on expert and intelligent systems, once it helps to develop a segmentation method with lower required specialist knowledge, being robust and as efficient as state of the art techniques. We also constructed an automatic point selection process based on the simulated annealing optimization method, avoiding the need of human intervention. The proposed approach was qualitatively compared with other state-of-the-art segmentation techniques, considering the shape of segmented regions. In order to validate our proposal, we built an image classifier using a classical multilayer perceptron. We used Zernike moments to extract segmented image features. This analysis employed 685 mammograms from IRMA breast cancer database, using fat and fibroid tissues. Results show that the proposed technique could achieve a classification rate of 91.28% for fat tissues, evidencing the feasibility of our approach. (C) 2016 Elsevier Ltd. All rights reserved.