Genetics of stroke: a review of recent advances

摘要

Stroke is a multifactorial disease responsible for nearly 10% of deaths each year innindustrialized countries. While some monogenic forms of stroke have been described, the vastnmajority result from the common polygenic form of the disease. Progress in molecular geneticsnhas allowed the identification, through genome-wide linkage analysis, of various candidatengenes, including the genes encoding PDE4D and ALOX5AP. Since then, genetic research hasnbeen extensively performed from single candidate genes to whole-genome scan studies, innparallel with the development of high-throughput technologies in molecular diagnostics.nAdditionally, the safety and efficacy of tissue plasminogen activator, the only approved therapynfor the acute phase of stroke, is modulated by genetic background associated with thenoccurrence of hemorrhagic transformations and with the revascularization of the cerebralnarteries. In the near future, understanding the contribution of stroke genetic factors will leadnto improvements in prevention and treatments for neurovascular diseases.