Production of WTC.ZI-zi Rat Congenic Strain and Its pathological and Genetic Analyses

摘要

A new rat congenic strain, WTC. ZI-zi, was produced after eleven generations of backcrossing between ZI strain as a donor strain and WTC strain as an inbred partner. WTC. ZI-zi/zi homozygous rats generally exhibit more conspicuous body tremor and much Earlier occurrence of flaccid paresis than the original ZI strain. The average life span of the Congenic strain is approximately nine months, which is also much shorter than that of the Original ZI strain. Pathological analysis of the central nervous system of the congenic strain Revealed more aggravated vaculoation and hypomyelination than in the original ZI strain.