The use of 18F-fluoride and 18F-FDG PET scans to assess fracture healing in a rat femur model

W. K. Hsu; B. T. Feeley; L. Krenek; D. B. Stout; A. F. Chatziioannou; J. R. Lieberman

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The use of 18F-fluoride and 18F-FDG PET scans to assess fracture healing in a rat femur model

机译：18 F-氟化物和18 F-FDG PET扫描在评估大鼠股骨模型骨折愈合中的作用

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Currently available diagnostic techniques can be unreliable in the diagnosis of delayed fracture healing in certain clinical situations, which can lead to increased complication rates and costs to the health care system. This study sought to determine the utility of positron emission tomography (PET) scanning with 18F-fluoride ion, which localizes in regions of high osteoblastic activity, and 18F-fluorodeoxyglucose (FDG), an indicator of cellular glucose metabolism, in assessing bone healing in a rat femur fracture model.

机译：当前可用的诊断技术在某些临床情况下对延迟骨折愈合的诊断可能不可靠，这可能导致并发症发生率增加和医疗保健系统成本增加。这项研究试图确定正电子发射断层扫描（PET）扫描在18 F氟离子（FDG）和18 F氟离子位于局部成骨细胞活性高的区域中的实用性葡萄糖代谢在评估大鼠股骨骨折模型的骨愈合中的作用。

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来源
《European Journal of Nuclear Medicine and Molecular Imaging 》 |2007年第8期| 1291-1301| 共11页
作者
W. K. Hsu; B. T. Feeley; L. Krenek; D. B. Stout; A. F. Chatziioannou; J. R. Lieberman;
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作者单位

Department of Orthopaedic Surgery David Geffen School of Medicine at UCLA Center for Health Sciences 76-134 10833 LeConte Avenue Los Angeles CA 90095 USA;

Department of Orthopaedic Surgery David Geffen School of Medicine at UCLA Center for Health Sciences 76-134 10833 LeConte Avenue Los Angeles CA 90095 USA;

Department of Orthopaedic Surgery David Geffen School of Medicine at UCLA Center for Health Sciences 76-134 10833 LeConte Avenue Los Angeles CA 90095 USA;

Department of Orthopaedic Surgery David Geffen School of Medicine at UCLA Center for Health Sciences 76-134 10833 LeConte Avenue Los Angeles CA 90095 USA;

Department of Orthopaedic Surgery David Geffen School of Medicine at UCLA Center for Health Sciences 76-134 10833 LeConte Avenue Los Angeles CA 90095 USA;

The Musculoskeletal Institute Department of Orthopaedic Surgery University of Connecticut Health Center 263 Farmington Avenue Farmington CT 06030-5456 USA;

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正文语种 eng
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关键词
18F-FDG; Positron emission tomography; Bone; 18F-fluoride ion; Fracture nonunion;

机译：18F-FDG;正电子发射断层扫描;骨;18F-氟离子;断裂不愈合;

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专利

1. The use of 18F-fluoride and 18F-FDG PET scans to assess fracture healing in a rat femur model. [J] . Hsu WK, Feeley BT, Krenek L, European Journal of Nuclear Medicine and Molecular Imaging . 2007 ,第8期

机译：使用18F-氟化物和18F-FDG PET扫描评估大鼠股骨模型中的骨折愈合情况。
2. Evaluation of New Bone Formation in Normal and Osteoporotic Rats with a 3-mm Femur Defect: Functional Assessment with Dynamic PET-CT (dPET-CT) Using 2-Deoxy-2-[18F]Fluoro-d-glucose (18F-FDG) and 18F-Fluoride [J] . ChengC., AltV., Dimitrakopoulou-StraussA., Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging . 2013 ,第3期

机译：正常和骨质疏松大鼠股骨3毫米缺损中新骨形成的评估：使用2-脱氧-2- [18F]氟-d-葡萄糖（18F-FDG）进行动态PET-CT（dPET-CT）功能评估和18F-氟化物
3. Novel Strategy for a Cocktail 18F-Fluoride and 18F-FDG PET/CT Scan for Evaluation of Malignancy: Results of the Pilot-Phase Study. [J] . Iagaru A, Yaghoubi SS, Quon A, The Journal of Nuclear Medicine . 2009 ,第4期

机译：鸡尾酒18F-氟化物和18F-FDG PET / CT扫描评估恶性肿瘤的新策略：中试研究的结果。
4. Exploit ~18F-FDG Enhanced Urinary Bladder in PET Data for Deep Learning Ground Truth Generation in CT Scans [C] . Christina Gsaxner, Birgit Pfarrkirchner, Lydia Lindner, SPIE Medical Imaging Conference . 2018

机译：在PET数据中利用〜18F-FDG增强型膀胱膀胱在CT扫描中生成深度学习地面真相
5. Biomechanical Evaluation of Hybrid, Bicortical and Unicortical, Screw Configurations for Internal Bone Plate Fixation of Long Bone Fracture: An In-Vitro Study of Porcine Femur Bone Models. [D] . Gonzalez Quintero, Gabriel Jonas. 2017

机译：混合，双皮质和单皮质，螺钉构型对长骨骨折内部骨板固定的生物力学评估：猪股骨模型的体外研究。
6. The use of 18F-fluoride and 18F-FDG PET scans to assess fracture healing in a rat femur model [O] . W. K. Hsu, B. T. Feeley, L. Krenek, -1

机译：使用18F-氟化物和18F-FDG PET扫描评估大鼠股骨模型中的骨折愈合
7. The use of 18F-fluoride and 18F-FDG PET scans to assess fracture healing in a rat femur model [O] . Lieberman, Jay R 2007

机译：使用18F-氟化物和18F-FDG PET扫描评估大鼠股骨模型中的骨折愈合

The use of 18F-fluoride and 18F-FDG PET scans to assess fracture healing in a rat femur model

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