The influence of air pollution on cardiovascular and pulmonary function and exercise capacity: Canadian Health Measures Survey (CHMS)

摘要

Background: Air pollution has been associated with adverse cardiovascular effects. Objective: To measure the association between air pollution, spirometry, blood pressure, and exercise capacity. Methods: We used data from 5604 subjects collected during the Canada Health Measures Survey to test the association between air pollution measured on the day of the survey and spirometry (n = 5011 subjects), blood pressure, and exercise capacity (n = 3789 subjects). Results: An interquartile range (IQR) increase in ozone (17.0 ppb) was significantly associated with a 0.883% higher resting heart rate, a 0.718% higher systolic and 0.407% higher diastolic blood pressure, a 0.393% lower FEV_1/FVC expressed as a percentage of predicted, and a 1.52% reduction in the aerobic fitness score (p < 0.05). Resting systolic and diastolic blood pressure were approximately 0.5 mmHg higher for an (IQR 4.5 μg/m~3) increase in PM2.5 (IQR 4.5 μg/m~3) and 1 mmHg higher for a 12.6 ppb increase in NO_2 (IQR 12.6 ppb). An increase in PM_(2.5) was also associated with an approximate 0.4% decrease in percent predicted FEV) and FVC (p < 0.05). Conclusion: Exposure to higher concentrations of air pollution was associated with higher resting blood pressure and lower ventilatory function. Ozone was associated with reduced exercise capacity.