Pharmacokinetics and Metabolic effects of High-Dose Growth Hormone Administration in Healthy Adult Men

摘要

to evaluate pharmacokinetics of growth hormone (GH) and its effects on IGF-I, glucose, insulin, non- esterified fatty acid (NEFA) and triglyceride (TG), fifteen japanese healthy adult male volunteers (20-27 years old) were studied. The subjects were divided into three groups, and received with a single s. C. in ection of 0.075, 0.15 and 0.30 IU/kg of GH, Cmax and AUC of GH were increased in a dose-dependent manner.