Clinical Characteristics of Amiodarone-Induced Thyrotoxicosis and Hypothyroidism in Japan

摘要

Since amiodarone was introduced in Japan in 1992, the incidence of the drug-induced thyroid dysfunction has been increasing. We studied the thyroid function of 13 patients with amiodarone-induced thryo- toxicosis (AIT) and 11 patients with amiodarone-associated hypothyroidism (AAH) who had been referred to our Institute in the last 6 years. AIT and AAH developed after 39 ± 21 and 20 ± 16 months of amiodarone treatment, Respectiely. One patient developed AAh followed by AIT. The AiT ranged from subclinical to overt thyrotoxi- Cosis.