identification of Glucagon-Like Peptide 1 (GLP-1) Actions Essential for Glucose Homeostasis in Mice With Disruption of GLP-1 Receptor Signaling

摘要

Glucgon-like peptide-1 (GLP-1) acts to control blood glucose via multiple mechanisms, including regulation of insulin and glucagon secretion, gastric emptying, satiety, and peripheral insulin sensitivity. However, the relative importance of these actions for regulation of blood glucose remains unclear. We demonstrate here a gene dosage effect for the incretin action of GLP-1, as heterozygous GLP-1R+/- mice exhibit an abnormal glycemic response to oral glucose challenge in associa- tion with reduced circulating levels of glucose-stimu- lated insulin.