Elimination of Glucagon-Like Peptide 1R Signaling Does Not Modify Weight Gain and Islet Adaptation In Mice With Combined Disruption of Leptin and GLP-1 Action

摘要

Leptin and glucagon-like peptide 1 (GLP-1) exhibit opposing actions in the endocrine pancreas. GLP-1 stimulates insulin biosynthesis, secretion, and islet growth, whereas lepth inhibits glucose-dependent insulin secretion and insulin gene transcription. In con- trast, GLP-1 and leptin actions overlap in the central nervous system, where leptin has been shown to acti- vate GLP-1 circuits that inhibit food intake.