Overnight Lowering of Free Fatty Acids With Acipimox Improves Insulin Resistance and Glucose Tolerance in Obese Diabetic and Nondiabetic Subjects

摘要

Obesity is commonly associated with elevated plasma free fatty acid (FFA) levels, as well as with insulin resistance and hyperinsulinemia, two important car- diovascular risk factors. What causes insulin resis- tance and hyperinsulinemai in obesity remains uncer- tain. Here, we have tested the hypothesis that FFAs are the link between obesity and insulin resistance/hyper- insulinemia and that, therefore, lowering of chroni- cally elevated plasma FFA levels would improve insulin resistance/hyperinsulinemia and glucose tolerance in obese nondiabetic and diabetic subjects.