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国际内分泌代谢杂志

国际内分泌代谢杂志

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International Journal of Endocrinology and Metabolism
1981年创刊，中华人民共和国卫生部主管，中华医学会、天津医科大学主办。本刊是国家级学术期刊，由我国著名的医学内分泌学先驱——朱宪彝教授创办。以印刷版及电子版在国内外公开发行。本刊办刊宗旨为及时、准确、全面地介绍内分泌学领域的国际新动态、新技术、新药物及新进展。栏目设有“专家论坛”、“述评”、“临床热点话题”、“综述”、“论著”、“会议精粹”、“大型学术会议专栏”、“继续医学教育”、“网上快讯”等。
  • 发文量：3484
  • 被引量：851
  • H指数：2
  • 开始收录时间：1989,9(1)
  • CNKI综合因子：0.442
  • 维普期刊影响因子： 0.665
  • 万方期刊影响因子：0.73
  • 创刊时间：1981
  • 国内刊号/CN：12-1383
    国际刊号/ISSN：1673-4157
  • 发行周期：双月刊
    邮发代号：6-53
  • 主管单位：中华人民共和国卫生部
    主办单位：中华医学会；天津医科大学
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  • 邮箱：nfmfc@126.com
  • 地址：天津市和平区气象台路22号天津医科大学院内
  • 邮编：300070
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国际内分泌代谢杂志 >2021年第6期

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  • 摘要：Along with the wide use of glucagon-like peptide-1 ( GLP-1 ) receptor agonists,evidence has been accumulated that GLP-1 receptor agonists could lead to myocardial protection,improvement of myocardial infarction and heart failure by ways of regulating blood glucose,lipid and blood pressure,anti-inflammation and anti-oxidative stress,etc.%随着胰高血糖素样肽-1( GLP-1)受体激动剂的广泛应用,越来越多的研究表明,此类药物能够通过调节血糖、血脂、血压,并通过抗炎、抗氧化应激等机制,发挥保护心肌、改善心肌梗死和心力衰竭等方面的效应.
  • 摘要：脂蛋白脂肪酶(LPL)是甘油三酯(TC)水解的限速酶,其基因缺失和基因多态性与糖、脂代谢紊乱的发生、发展密切相关.LPL功能紊乱可引起胰岛素抵抗甚至糖尿病,其可能机制包括:脂质异位沉积与胰岛素信号转导通路受损、内质网应激、氧化应激、炎性反应.明确LPL在糖尿病发生、发展中的作用,为防治糖尿病提供了新的思路.%Lipoprotein lipase (LPL) is the rate-limiting enzyme in the lipolysis of plasma triglyceride-rich lipoprotein.LPL ablation and its single nucleotide polymorphisms are closely related to the occurrence and development of glucose and lipid metabolism disorders.The dysfunction of LPL can cause insulin resistance or even diabetes.The possible mechanisms include:ectopic lipid deposition and the abnormity in the insulin signaling pathway,endoplasmic reticulum stress,oxidative stress,inflammation.Clarifying the role of LPL in the occurrence and development of type 2 diabetes will provide new ideas for the treatment of diabetes.
  • 摘要：Regulatory B cells(Bregs) play important roles in the occurrence,development and outcomes of autoimmune diabetes.They secrete suppressive cytokines such as interleukin-10 (IL-10) and transforming growth factor-β1 ( TGF-β1 ) to induce immunologic tolerance.Bregs inducing TGF-β1 secretion in vitro provides a new treatment of autoimmune diabetes.When using anti-CD20 monoclonal antibody to treat autoimmune diabetes,there is an increase in Bregs population.%调节性B细胞在自身免疫性糖尿病的发生、发展、转归过程中起重要调节作用.通过产生白细胞介素-10(IL-10)和转化生长因子-β1(TGF-β1)等抑制性细胞因子介导免疫耐受.体外诱导分泌TGF-β1的调节性B细胞可以为自身免疫性糖尿病的治疗提供新的方法.抗CD20单克隆抗体治疗自身免疫性糖尿病可使调节性B细胞数量增加.
  • 摘要：Recently,some scholars found that overexpression and activation of 12/15-lipoxygenase may contribute to the progress of diabetic nephropathy and neuropathy.12/15-1ipoxygenase can catalyze arachidonic acid to produce 12( S)- and 15 ( S)- hydroxyeicosatetraenoic acids,which may affect cell structure,metabolism and signal transduction.Some studies showed that 12/15-lipoxygenase and its metabolites can directly induce and indirectly regulate cytokines,leading to cell hypertrophy,proliferation and extracellular matrix deposition,which participate in the development of diabetic nephropathy.Moreover,overexpression and activation of 12/15-lipoxygenase could be related to oxidative and nitrative stress of the peripheral nervous system,which is probably involved in the onset of diabetic neuropathy.Therefore,12/15-lipoxygenase inhibitors and 12/15-lipoxygenase inhibitor-containing combination therapies may provide a new research direction for diabetic microvascular complications.%最近研究发现,12/15-脂加氧酶的过表达或激活可能促进了糖尿病肾病和神经病变的进展.该酶可催化花生四烯酸产生12-羟基二十碳四烯酸和15-羟基二十碳四烯酸,从而影响细胞结构、代谢和信号转导.研究发现12/15-脂加氧酶及其代谢产物可直接诱导或间接调节细胞因子导致细胞肥大、增殖和细胞外基质堆积,参与糖尿病肾病的发生.此外,该酶的过表达和激活与外周神经系统的氧化-硝化应激相关,可能参与糖尿病神经病变的发生.因此,12/15-脂加氧酶抑制剂或包含抑制剂的联合治疗可能为糖尿病微血管并发症的治疗提供新的研究方向.
  • 摘要：脂联素作为重要的脂肪因子,在血浆中有低、中、高分子量多聚体3种类型,其中高分子量(HMW)脂联素是脂联素主要的活性形式.研究发现,其降低与胰岛素抵抗密切相关.非酒精性脂肪性肝病(NAFLD)作为代谢综合征的表现之一,发病率也逐年攀升,合并NAFLD的患者HMW脂联素水平下降,胰岛素抵抗程度加重,主要与肝脏炎性反应加重、胰岛素的敏感性下降、脂代谢异常有关.调节脂联素水平对NAFLD的防治具有一定临床意义.%As an important adipocytokine,adiponectin has three multimers isoforms in the plasma including low molecular weight trimer,medium molecular weight hexamer and high molecular weight (HMW)multimers,among which the latter is the most active complex.Evidences show that decreased HMW adiponcetin is strongly associated with insulin resistance.The prevalence of nonalcoholic fatty liver disease ( NAFLD),one of the components of metabolic syndrome,is increasing.The decreased serum level of H M W adiponectin and insulin resistance was observed in patients with NAFLD,which involved in aggravated inflammation,lower insulin sensitivity and lipid metabolism dysfunction in the liver.Regulate the concentration of HMW adiponectin is of great importance for the prevention of NAFLD.
  • 摘要：Obese patients tend to have mandibular and parapharyngeal fat deposition and airway obstruction,leading to obstructive sleep apnea hypopnea syndrome (OSAHS),which may be used as a predictor of OSAHS.OSAHS is a disease,characterized by recurrent upper airway collapse leading to sleep apnea and repeated hypoxia.It can cause a series of endocrine and metabolic abnormalities.Abnormal lipid metabolism,decline of insulin sensitivity and leptin resistance at midnight in patients with OSAHS play roles in the occurrence and development of obesity.%肥胖患者下颌及咽周脂肪沉积阻塞气道,可导致阻塞性睡眠呼吸暂停低通气综合征(OSAHS),可能作为OSAHS的预测指标.OSAHS是一种由于睡眠期间反复发生上气道塌陷导致睡眠呼吸暂停以及反复低氧的一种疾病,可引起一系列内分泌和代谢异常.OSAHS患者夜间缺氧可导致脂代谢异常、胰岛素敏感性下降、瘦素抵抗,从而在肥胖的发生、发展中起一定作用.
  • 摘要：抑瘤素M(OSM)是白细胞介素-6超家族成员,是一种多功能的细胞因子,参与细胞生长、分化、炎性反应、造血过程以及组织重塑等多种生物学过程.近年来研究发现,OSM与糖尿病及其血管并发症密切相关,确切的机制尚不清楚,可能是通过自分泌和旁分泌的方式,促进自身和其他细胞因子的分泌,参与胰岛素抵抗、肥胖等的发生,从而导致糖尿病及其血管损伤.%Oncostatin M( OSM ) is a multifunctional cytokine which belongs to the interleukin ( IL)-6subfamily.OSM involves in many biological activities such as the growth and differentiation of cells,inflammation,hemopoiesis,as well as tissue remodeling.Recent studies show that OSM has a close relationship with diabetes and its vascular complications.However,the definite mechanisms are still unknown.OSM might induce the secretion of itself and other cytokines by autocrine and paracrine manners,participate in insulin resistance and obesity,leading to the pathogenesis of diabetes and its vascular injury.
  • 摘要：血清和糖皮质激素诱导的蛋白激酶1( SGK1)是一种丝氨酸/苏氨酸蛋白激酶,受多种因素的调控,参与调节多种生理功能.近年来研究表明,SGK1的表达及活性增加参与多种病理过程,与高血压、肥胖、糖尿病等的发生、发展密切相关.全面理解SGK1的生理功能,及其与代谢综合征的相关性及机制具有重要的意义.SGK1可能作为代谢综合征及相关组分治疗的新靶点.%Serum- and glucocorticoid-induced protein kinase 1 (SGK1) is one of serine/threonine protein kinases,which is regulated by many factors and involved in the regulation of various physiological functions.Recent studies indicate that the expression and activation of SGK1 participates in several pathological conditions and also plays an important role in the development of hypertension,obesity,diabetes,etc.It is necessary to fully understand its physiological function,mechanism and relationship between SGK1 and metabolic syndrome.SGK1 may become a new probable target for the treatment of metabolic syndrome and its related components.
  • 摘要：Objective To investigate the efficacy and safety of liraglutide monotherapy or in combination with metformin,insulintrophic agents in the treatment for Chinese patients with type 2 diabetes.Methods 60 patients without hypoglycemic agents,114 patients poorly controlled by metformin and 46 by insulintrophic agents,were enrolled in this multi-center,self-controlled and open-labeled clinical study.All patients were initiated with 0.6 mg liraglutide without changing their basal oral hypoglycemia agents and increased 0.6 mg every 2 weeks if fasting blood glucose (FBG) did not reach the criteria.The maximum dosage was 1.8 mg.The treatment lasted for 12 weeks,and the changes of blood glucose,weight and related index before and after treatment were measured.Results After treatment of liraglutide,mean FBG decreased ( 3.25 ± 1.04 ) mmol/L,and mean postprandial glucose decreased ( 4.97 ± 2.35 ) mmol/L( P ＜ 0.01 ).Mean HbAlc reduced from 8.15％ to 7.00％ (decreased by 1.15％);88 cases (40.00％) and 28 cases ( 12.73％ )obtained the glycemic target of HbAlc ＜ 7％ and HbAlc ＜ 6.5％ respectively.The mean body weight decreased 8 kg,about two third decreased by more than 5％ and the rest declined by no less than 10％.The extent of weight decline was dependent on body mass index (BMI) at baseline(x2 =12.102,P =0.017).The mean waist circumference decreased from 96.5 cm to 89.0 cm (P ＜0.0l ).At the same time,systolic blood pressure (SBP) and mean diastolic blood pressure (DBP) decreased ( 5.26 ± 3.11 ) and (3.10 ±2.05) mm Hg separately ( lmm Hg =0.133 kPa,P ＜0.01 ).The incidence of hypoglycemia was 2.73％,and no serious hypoglycemia occurred.Conclusions Liraglutide monotherapy or in combination with metformin,insulintrophic agents is efficient in glycemic control,and beneficial for body weight loss and blood pressure reduction,which also possess a lower incidence of hypoglycemia in Chinese patients with type 2 diabetes.%目的 研究利拉鲁肽单用或与二甲双胍、胰岛素促泌剂联用对中国2型糖尿病患者的有效性和安全性.方法 为多中心、自身对照、开放式临床研究,60例未接受药物治疗、114例已使用二甲双胍、46例已使用胰岛素促泌剂而血糖仍未达标的患者在原治疗基础上,联合利拉鲁肽0.6 mg降糖,并根据空腹血糖是否达标每2 周增加0.6 mg,最大剂量1.8 mg.治疗持续12周,观察治疗前、后血糖、体重等相关指标的变化.结果 利拉鲁肽治疗后,患者的平均空腹血糖下降(3.25±1.04)mmol/L,平均餐后血糖下降(4.97±2.35) mmol/L(P ＜0.01).平均糖化血红蛋白(Hb) Alc由治疗前的8.15％下降至7.00％,下降了1.15％;有88例(40.00％)及28例患者(12.73％)分别达到HbAlc＜7％及HbAlc ＜6.5％的控制目标.患者平均体重下降8 kg,其中约2/3体重下降5％以上,其余体重下降10％以上.体重下降幅度随基线体重指数(BMI)升高而明显升高,基线BMI越高体重下降越明显(x2=12.102,P=0.017).腰围由治疗前平均96.5 cm下降至89.0 cm(P＜0.01).同时患者平均收缩压及舒张压分别下降(5.26±3.11)及(3.10±2.05)mm Hg(1 mm Hg=0.133 kPa,P＜0.01).低血糖发生率为2.73％,且无严重低血糖事件发生.结论 在中国2型糖尿病患者中,应用利拉鲁肽单药治疗或与二甲双胍或胰岛素促泌剂联合治疗,可有效控制血糖、减轻体重、降低血压且低血糖风险小.
  • 摘要：Objective To investigate the effect of adiponectin on early stage of diabetic nephropathy and the possible mechanism.Methods Murine diabetic models were induced with streptozotocin (STZ).All rats were randomized divided into normal control group( NC group),diabetic group ( DM group),and pioglitazone therapy group( 15 mg· kg-1 · d-1,PT group).The body weight was measured every week,and blood glucose was determined every two weeks.All rats were killed after 8 weeks,and then serum adiponectin levels,related biochemical data and indicators of renal function were measured.At the same time,the liquid nitrogen frozen specimens from renal cortex were taken to analyze the level of adiponectin,transforming growth factor(TGF) -β1 mRNA by real time RT-PCR.The expression of TGF-β1 protein was determined by immunohistochemistry.Results Compared with NC group,the levels of blood glucose,blood urea nitrogen,24 h urine and urinary microalbumin,renal hypertrophy index were significantly higher in DM group( P ＜ 0.01 ),whereas the levels of serum creatinine and adiponectin were significantly lower( P ＜ 0.01 ).Compared with DM group,PT group only had a short-term hypoglycemia during the early stage of experiment.Glucose level in later stage between DM and PT group had no statistical difference.However,in PT group,serum adiponectin level increased (P ＜0.05) while blood urea nitrogen,24 h urine and urinary microalbumin,renal hypertrophy index decreased significantly ( P ＜ 0.01 ) compared with DM group.Real-time PCR showed that compared with NC group,adiponectin mRNA expression decreased,while TGF-β1 mRNA expression was significantly enhanced in DM group.Compared with DM group,adiponectin mRNA level in PT group was increased (P＜0.05),whereas TGF-β1mRNA expression was significantly inhibited (P＜0.01 ).Conclusions Adiponectin plays an important role in diabetic nephropathy.Pioglitazone can inhibit the expression of TGF-β1 mRNA and protein by enhancing the expression of adiponectin in kidney,thus plays an independent protective effects of the kidney.%目的 探讨脂联素在早期糖尿病肾病中的作用及其可能的作用机制.方法 建立链脲佐菌素(STZ)诱导的糖尿病动物模型,随机分为正常对照组(NC组)、糖尿病组(DM组)、吡格列酮治疗组[15mg/( kg·d),PT组].每周测量体重,每两周测定血糖,于实验第8周末处死大鼠后测定血清脂联素水平、相关生化指标及肾功能指标,同时留取肾皮质液氮冻存与福尔马林固定,应用实时定量逆转录(RT)-PCR方法检测肾皮质脂联素受体、转化生长因子(TGF)-β1的mRNA水平,免疫组织化学法测定TGF-β1蛋白的表达情况.结果 与NC组相比,DM组大鼠血糖、血尿素氮、24h尿量及尿微量白蛋白、肾肥大指数明显升高(P＜0.01),血肌酐含量和血清脂联素水平明显下降(P＜0.01).与DM组比较,PT组仅在实验前期出现短暂的血糖降低,后期血糖水平差异无统计学意义,但PT组血清脂联素水平升高(P＜0.05),血尿素氮、24 h尿量及尿微量白蛋白、肾肥大指数等指标明显下降(P＜0.01).实时RT-PCR结果显示,与NC 组比较,DM组的脂联素mRNA表达量下降,而TGF-β1mRNA表达明显升高;与DM组相比,PT组脂联素mRNA水平升高(P＜0.05),而TGF-β1 mRNA表达明显受抑制(P＜0.01).结论 脂联素对糖尿病肾病具有重要作用,吡格列酮可以通过增加脂联素在肾脏的表达来抑制TGF-β1mRNA及蛋白的表达,从而对肾脏发挥独立的保护作用.
  • 摘要：Objective To explore the effects of triperygium wilfordii polyglucoside (TWP) on proteinuria,podocytes damages,nephrin expression in rats with diabetic nephropathy.Methods Diabetic nephropathy was established in rats using high lipids diet combined with streptozotocin (STZ).Diabetic rats were randomized into diabetic nephropathy model,low dosage of TWP( 6 mg · kg- 1 · d-1) and high dosage of TWP( 12 mg · kg-1 · d-1 )group.Normal rats were used as control and 12 rats for each group.After intervention for 12 weeks,24 h urinary protein excretion rate (UAER),serum creatinine and plasma urea nitrogen were accessed.The pathological changes of kidney were evaluated by Haematoxylin and eosin( HE),Periodic acid schiff(PAS),Masson staining.Ultrastructural alteration was examined by transmission electron microscope.The expressions of nephrin were evaluated by immunohistochemical staining.Results Compared with normal rats [ ( 3.28 ± 0.26 ) mg/24 h ],macroalbuminuia increased in diabetic rats [ ( 27.60 ± 0.24 ) mg/24 h],whereas the level of urine protein significantly decreased in 6 and 12 mg · kg-1 · d-1 TWP treatment for 12 weeks[ ( 12.63 ±0.21 ) and( 10.50 ± 0.15 ) mg/24 h ].There was no significant statistical difference between high and low dose of TWP group( P ＜0.05 ).In renal pathologic examination of diabetic nephropathy model group,the glomerular were sclerosis,with thicker basement membranes,deformed renal tubules,vacuolar degenerated epithelial cells and sclerosed interstitial were observed.The foot processes of podocyte were widen and fused,and the number of podocyte was also decreased.However,the kidney and podocyte lesions were improved significantly both in high and low dose of TWP groups.The expressions of nephrin by immunohistochemistry were also increased in both TWP treatment groups,with more statistical improvement in high dose group.Conclusions TWP may exert its protective effect on podocytes function in diabetic nephropathy through increasing nephrin expression.%目的 探讨雷公藤多苷(TWP)对糖尿病肾病大鼠尿蛋白、足细胞损伤及肾皮质nephrin 蛋白表达的影响.方法 建立高脂饮食联合链脲佐菌素诱导糖尿病肾病大鼠模型,随机分为糖尿病肾病模型组、小剂量TWP(6 mg·kg-1·d-1)治疗组及大剂量TWP(12 mg·kg-1·d-1)治疗组,并以正常大鼠为对照,每组12只.干预12周后检测大鼠24 h尿蛋白量、血肌酐及尿素氮水平,并以苏木素-伊红染色(HE)、过碘酸希夫染色(PAS)、Masson染色检测肾组织病理变化;透射电镜测量足细胞超微结构变化;免疫组化检测肾皮质nephrin蛋白表达.结果 与正常大鼠相比,2型糖尿病大鼠尿蛋白明显增加[( 3.28±0.26) mg/24 h vs.(27.60±0.24) mg/24 h],而小剂量及大剂量TWP治疗后大鼠尿蛋白均明显改善[分别为(12.63 ±0.21)及(10.50±0.15) mg/24 h,P＜0.05)],大剂量TWP治疗组尿蛋白低于小剂量TWP治疗组,但差异末达统计学意义.病理分析显示糖尿病肾病模型组表现为肾小球硬化、基底膜增厚,肾小管变形、上皮细胞空泡变性,间质纤维化,足细胞足突增宽、融合、细胞减少,TWP治疗组大鼠肾小球、小管间质及足细胞病变明显减轻.同时免疫组化结果显示TWP治疗使肾脏皮质nephrin蛋白表达增加,且大剂量TWP治疗组高于小剂量TWP治疗组.结论 TWP可能通过增加nephrin的表达,发挥其对糖尿病肾病足细胞功能的保护作用.
  • 摘要：长期睡眠紊乱可改变机体神经-内分泌功能,使血中升血糖激素、细胞因子水平升高,引起胰岛素抵抗、肥胖等病理生理改变,导致糖尿病的患病风险明显升高.同时,糖尿病引起的中枢神经系统与神经递质异常,急、慢性并发症的发生、发展,及其所带来的心理负担等,都极易影响患者的睡眠模式和质量,引起睡眠紊乱.糖尿病与睡眠紊乱关系密切,改善睡眠质量可明显提高胰岛素敏感性,改善血糖控制,起到辅助治疗糖尿病的作用.%Long-term sleep disorder may cause significantly change of neural incretion function,increase the level of plasma hormones that raise glucose level and adipokines,which results in pathophysiological changes including insulin resistance and obesity,and increase the risk of diabetes mellitus.At the same time,the disorders caused by diabetes mellitus,such as the abnormity of neural system and neurotransmitter,the development of acute and chronic complications and the psychological burden,could affect the patients' sleeping mode and quality and lead to sleeping disorder.Diabetes mellitus and sleep disorder have close relationship.Improving sleep quality can obviously improve insulin sensitivity and glycemic control,which plays an indeed role for the auxiliary therapy for diabetes.
  • 摘要：Advanced glycation end products (AGEs) increased or accumulated in the body may get rise to cell dysfunction and promote diabetic microvascular complications,especially the development of diabetic nephropathy (DN).AGEs can cause the functional and structural changes of the kidney.Though focusing on different points of signal pathway,a number of new agents,such as inhibitors and breakers of AGEs,receptor antagonists for AGEs and inhibitors to the signal transduction pathway after AGEs receptor,can decrease the negative effect of AGEs on target organs and play therapeutic roles in DN.%晚期糖基化终末产物(AGEs)在体内的增加、蓄积会引起各种细胞功能障碍,促进糖尿病微血管并发症特别是糖尿病肾病的发生和发展.AGEs可引起肾脏功能障碍和结构改变.针对AGEs的药物如抑制AGEs形成的药物、AGEs交联裂解剂、阻断AGEs及其受体相互作用的药物、抑制AGEs受体的表达及其下游路径的药物,分别作用于不同的信号通路环节,但都具有减少AGEs对靶器官损伤的作用,对糖尿病肾病具有一定的治疗作用.
  • 摘要：Lymphocytic hypophysitis (LYH) is a rare autoimmune endocrine disease characterized by the lymphocytic infiltration in the pituitary gland.LYH mainly presents as intracranial space-occupying,anterior pituitary dysfunction and/or central diabetes insipidus,and should be differentiated with other types of sellar lesions.Glucocorticoids treatment can effectively reduce the lesion and improve the function of pitui%淋巴细胞性垂体炎(LYH)是一种较少见的自身免疫性内分泌疾病,以垂体组织内淋巴细胞浸润为特征,主要表现为颅内占位、垂体前叶功能减退和(或)中枢性尿崩症,需与其他类型的鞍区占位性病变鉴别.糖皮质激素治疗可以有效缩小病变并改善垂体功能.
  • 摘要：As a kind of intestinal endocrine cells,K cells scatter in the gastrointestinal tract,decreasing from the duodenum to the rectum,and secreting glucose-dependent insulinotropic polypeptide (GIP).Through the studies of STC-1 cell lines and fluorescently labeled K cells of transgenic mice,the mechanism of the three major nutrients in the regulation of GIP secretion has gradually been revealed.The density of K cells and GIP content increase under obesity,and GIP resistance in islet β cell exists in type 2 diabetes.Preventing K cells hyperplasia or reducing GIP production may be a new therapeutic option to treat obesity.Utilizing a patient's own K cells to reestablish endogenous meal-regulated insulin secretion represents a potential strategy to treat diabetes.%K细胞作为一种肠道内分泌细胞,零散分布于胃肠道,从十二指肠至直肠递减,分泌葡萄糖依赖性促胰岛素多肽(GIP).通过对STC-1细胞系及荧光标记K细胞的转基因小鼠的研究,三大营养物质调控GIP分泌的机制已逐步明了.肥胖状态存在K细胞数量及GIP含量的增加,而2型糖尿病则存在胰岛β细胞的GIP抵抗.减少K细胞增生或降低GIP分泌可能是一种新的减肥措施.利用患者自身K细胞,重新恢复内源性进餐刺激的胰岛素分泌,有单成为治疗糖尿病的潜在策略.
  • 摘要：The growth retardation is a common clinical manifestation in primary hypothyroidism-associated pituitary hyperplasia (PHAPH) during adolescents.Three PHAPH cases manifested with the growth retardation were reported.Their clinical and imaging features were analyzed.The efficacy and safety of the regimen with small starting dose of levothyroxine and short time increasing to a therapeutic dosage were investigated.%生长发育迟缓为青少年原发性甲状腺功能减退症(甲减)并垂体增生的常见临床表现,此报道3例以生长发育迟缓为首诊原因的青少年原发性甲减并垂体增生病例,分析其临床和影像学特征;探讨左甲状腺素小剂量起始,短时间内增加到治疗剂量方案的疗效及安全性.
  • 摘要：Insulin resistance and lack of insulin secretion is the main pathogenesis of type 2 diabetes.Researches have shown that glucagon-like peptide-1 ( GLP-1 ) receptor agonists could effectively improve the function of pancreatic β cell,and promote the secretion of insulin.Moreover,GLP-1 receptor agonists could regulate signal transduction,increase adipocytes differentiation and glucose uptake,decrease expression of inflammation factors,reduce weight and so on.Therefore,it can improve insulin resistance,increase insulin sensitivity.%2型糖尿病的发病机制主要涉及胰岛素抵抗张胰岛素分泌缺乏.研究表明,胰高血糖素样肽-1受体激动剂在有效改善胰岛β细胞功能,促进胰岛素分泌的同时,还能够作用于细胞信号转导,促进脂肪细胞分化和葡萄糖摄取,并通过减轻相关炎性反应因子表达,降低体重等,改善胰岛素抵抗,增加胰岛素敏感性.
  • 摘要：The functional imbalance and the destruction in coupling mechanism between the osteoblasts and osteoclasts are main pathogenesis of osteoporosis and metabolic bone disease.The research on antiosteoporostic drugs usually focus on changing signal pathways of the osteoblasts and osteoclasts.The targets of recent studies on osteoblasts often concentrate on the parathyroid hormone (PTH) signaling and the Wnt signaling,etc.On the other side,the targets of the research on osteoclasts mainly focus on the receptor activator of nuclear factor κB and its ligand(RANK/RANKL) signaling and integrin αvβ3 signaling,etc.%成骨细胞和破骨细胞功能失衡以及耦联机制的破坏是骨质疏松和代谢性骨病的主要发病机制.抗骨质疏松药物的研发大多通过直接影响此两群细胞的信号和代谢通路而改变其活性.目前成骨细胞信号的研发靶点主要集中在甲状旁腺激素(PTH)通路和Wnt信号通路等,而破骨细胞则主要集中在核因子κB受体激活因子及其配体(RANK/RANKL)通路和整合素αvβ3通路等.
  • 摘要：Objective To assess the prevalence of diabetes in adults living in the Dagang Oilfield.Methods A total of 3000 adults over 20 years old who were taken examination between May 2009 and October 2011 at the examination center of Dagang Oilfield general hospital were screened.After a night of fasting,75 g oral glucose tolerance test were conducted for each subject.Fasting plasma glucose and postprandial 2 h glucose levels were measured to diagnose diabetes and pre-diabetes.Height,abdominal circumference,blood pressure,blood lipids were also assessed.Individuals with impaired glucose regulation [ impaired fasting glucose (IFG) + impaired glucose tolerance (IGT) ] underwent examination of 24 h urinary albumin and fundus photography.Results Prevalence of diabetes increased with age (3.6％ in 20 to 39-year-old group,11.9％ in 40 to 59-year-old group,21.6％ in over 60-year-old group) and weight [ population in body mass index (BMI) of 20.0～24.9 kg/m2 is 8.2％,25.0 to 27.9 kg/m2 is 13.6％,≥28 kg/m2 is 20.2％).24 h urinary albumin increased in 9.8％ of subjects with impaired glucose regulation and retinopathy were detected in 10.1％ of them.Conclusions The prevalence of diabetes and prediabetes in adults living in Dagang Oilfield is high.Thus,early diagnosis and prevention is particularly important.%目的 本研究旨在评估大港油田地区成人糖尿病的患病率.方法 对2009年5月至2011年10月在大港油田总医院查体中心体检的3000名20岁以上成年人进行研究.经过一夜禁食,受试者行75 g口服葡萄糖耐量试验,根据空腹血糖和餐后2h血糖水平来诊断糖尿病和糖尿病前期,同时测量身高、腹围、血压、血脂.对糖调节受损[空腹血糖受损(IFG)+糖耐量减低(IGT)]者行24h尿微量白蛋白及眼底照相检查.结果 糖尿病患病率随年龄增长而升高(20～ 39岁人群3.6％,40 ～ 59岁人群11.9％,大于 60岁人群21.6％),也随体重增加而升高.体重指数(BMI) 20.0 ～24.9 kg/m2人群8.2％ 25.0～27.9 kg/m2人群13.6％、≥28 kg/m2人群20.2％].糖调节受损者中9.8％出现24 h尿微量白蛋白升高,10.1％出现眼底病变.结论 大港油田地区成年人糖尿病和糖尿病前期患病率较高.早期诊断、早期预防尤为重要.
  • 摘要：Professor Bruce Soiegelman,received the The Banting Medal for Scientific Achievement at the American Diabetes Association's 72th Scientific Sessions in 2012.In the meeting,Soiegelman gave the speech:transcriptional control of adipogenesis--toward a new generation of therapeutics for metabolic disease.He described the discovery of Irisin,a key regulatory hormone in glucose metabolism,and the third type of adipose tissue-beige fat cell.His work includes:(1) PR domain containing 16 (PRDM16) controls a brown fat/skeletal muscle switch.(2) PRDM16 determines the thermogenic program of subcutaneous white adipose tissue in mice.(3) Beige adipocytes are a distinct type of thermogenic fat cell in mice and human.(4) Beige can be slimming.( 5 ) Brown-fat-like development of white fat and thermogenesis that mediated by PPAR-γ co-activator-1α are correlated with Irisin.%2012年第72届美国糖尿病协会(ADA)年会上,Bruce Soiegelman教授获得Banting科学成就奖.会上Soiegelman作了题为“转录调控脂肪形成——代谢性疾病的新一代治疗”的演讲.他报道了一种新发现的糖代谢关键调节激素——虹神素(Irisin)和第三类型脂肪——米色脂肪组织的脂肪细胞.其研究工作包括:(1 )PR域包含蛋白16(PRDM16)是控制棕色脂肪组织与骨骼肌组织相互转换的开关.(2) PRDM16决定小鼠皮下白色脂肪组织的产热方式.(3)米色脂肪细胞是小鼠和人类一种独特的产热脂肪细胞.(4)米色脂肪组织可用于减肥.(5)过氧化物酶体增殖物活化受体(PPAR)-γ协同刺激因子(PGC)-1α依赖的白色脂肪棕色样改变及产热作用与Irisin有关.
  • 摘要：目的 研究长期系统性强化教育干预对糖尿病并发症的影响.方法 采用前瞻性研究方法,强化教育干预组(干预组)、对照组各130例.对照组实施常规糖尿病治疗和糖尿病基本知识教育,干预组除接受与对照组相同的措施外,对糖尿病患者及家属进行系统性、个体化、一对一的指导与行为干预,试验前和试验后5年收集相关资料,以评价代谢变化及各种并发症的发生情况.结果 糖尿病教育干预5年后,干预组代谢指标控制均较对照组好,干预组的体重指数(BMI)、空腹血糖(FBG)、餐后2h血糖(2 hPBG),糖化血红蛋白(Hb) Alc、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)均低于对照组(P＜0.05)；高血压、糖尿病视网膜病变,糖尿病肾病、糖尿病神经病变、糖尿病性脑梗死、糖尿病性心脏病、糖尿病足病的发生率均低于对照组,差异有统计学意义(P＜0.05)；干预组的发生率分别为3.7％,3.9％,8.8％,8.8％,1.96％,1.96％,0.1％；对照组的发生率分别为33％,15.1％,23％,28％,9％,9％,9％.结论 对糖尿病患者进行长期系统性、个体化、一对一的全方位教育干预能全面持久的改善糖、脂代谢,减少或延缓各种并发症的发生和发展.%Objective To study the effect of long term health education on diabetic complications.Methods In this prospective study,260 patients with diabetes were recruited.All the patients were divided into intensive health education group (intervention group,n =130) and control group (n =130).Patients in both group were given routine treatment of diabetes and health education,while patients and their family members in intervention group were given systemic,individual,one-on-one instruction and behavior intervention.At the beginning and five years after the study,collected related data to evaluate the metabolic changes and the development of diabetic complications.Results Five years after the intervention,body mass index(BMI),fast blood glucose (FBG),postprandial 2 h blood glucose (2 hPBG),hemoglobulin A1c ( HbA1c),total cholesterol ( TC ),triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) in the intervention group were lower than the corresponding index in the control group(P ＜ 0.05 ).Compared with the control group,the incidence of hypertension,diabetic retinopathy,diabetic nephropathy,diabetic neuropathy,diabetic cerebral infarction,diabetic heart disease and diabetic foot in the intervention group were 3.7％,3.9％,8.8％,8.8％,1.96％,1.96％,0.1％,while the incidence of the complications in the control group were 33％,15.1％,23％,28％,9％,9％,9％,the difference had statistically significant(P ＜0.05).Conclusions The long term systemic and individual health education can improve glucose and lipid metabolism.It also can reduce or delay the occurrence and development of diabetic complications.
  • 摘要：5％-10％ of diabetic patients arise lower extremity infection,ulcer and deep tissue damage which occur as a consequeuce of neuropathy and various degrees of vasculopathy.Diabetic foot ulcers (DFUs) increase the risk of amputations,morbidity and mortality.Debridement is performed gradually,and may transform a chronic wound into an acute one,which including mechanical methods (eg.surgical debridement and maggot debridement) and non mechanical methods ( eg.enzymes and gel) to encounter different wounds.On the other hand,debridement is performed step by step until the bleeding or hard places.Sufficient debridement could decrease amputation in DFUs.%5％～10％的糖尿病患者由于合并神经病变及不同程度的血管病变而发生下肢感染、溃疡和(或)深部组织的损伤,进而增加了截肢、致残和致死的危险性.清创技术以逐步外科清创为原则,有把慢性伤口转变为急性伤口等作用.清创技术可分为机械性方法(如手术清创和蛆虫清创)和非机械性方法(如酶制剂和水凝胶),适用于不同的创面.清创应按照由外至里的步骤,直至出血或坚硬的地方.合理清创可减少糖尿病足溃疡的截肢率.
  • 摘要：Diabetic foot is a common complication in diabetic patients.Infections and poor prognosisof diabetic foot wounds are plaguing the majority of the world's clinicians and patients.Vacuum sealing drainage(VSD) could drain the wound,prevent bacterial invasion which contribute to clean the wound as quickly as possible.Furthermore,continuous negative pressure can significantly improve the state of local microcirculation.Therefore,VSD with particular mechanisms and processes plays multiple roles on the treatment of diabetic foot.%糖尿病足是糖尿病患者的主要并发症之一.而糖尿病足创面感染和不良预后正困扰着全球大多数医务人员及患者.负压封闭引流(VSD)能干燥创面、有效地防止细菌入侵而使创面很快清洁,且持续高负压状态能显著改善局部微循环状态.VSD对糖尿病足的治疗具有多重作用,其作用机制和操作过程具有一定的特殊性.
  • 摘要：Islet β cell failure during diabetic progression and hypoglycemia induced by anti-diabetic drugs have become the obstacles of diabetes treatment.G protein coupled receptor 119 ( GPR119) agonists can decrease blood glucose level and preserve islet β cell function without hypoglycemia.GPR119 is expressed both in islet β cells and enteroendocrine cells,and activation of GPR119 can enhance glucose-stimulated insulin secretion (GSIS),increase the secretion of glucagon-like peptide-1 ( GLP-1 ),and promote the activation of insulin promoter.These advantages mentioned above suggest that GPR119 agonists show a good prospect as a new kind of anti-diabetes drugs.%糖尿病病程中出现的胰岛β细胞功能衰竭和降糖药物引起的低血糖已成为糖尿病治疗的难点.应用G蛋白耦联受体119(GPR119)激动剂可以降低血糖水平,保护胰岛β细胞功能,且不产生低血糖.GPR119在胰岛β细胞和肠内分泌细胞中表达,其激活可增加葡萄糖刺激的胰岛素分泌( GSIS)和胰高血糖素样肽-t(GLP-1)的分泌,并增强胰岛素启动子的活性.GPR119激动剂表现出的诸多优势提示,其作为一类新的糖尿病治疗药物有良好的应用前景.
  • 摘要：小分子RNA(miR)是近年发现的一类广泛存在于动植物中的小分子非编码RNA,它通过抑制靶目标的转录或直接将其降解而发挥作用.miR-29是新近发现的与糖尿病及其并发症有密切关系的一类小分子RNA.研究发现,miR-29可直接参与糖尿病的基本病理生理过程,如参与胰岛素相关信号通路.同时也参与肾脏纤维化、视网膜神经元凋亡等过程,从而在糖尿病肾病、糖尿病视网膜病变等糖尿病并发症的发生中起重要作用.%MicroRNAs (miR)are novel small,noncoding RNAs in animals and plants,whose function is to suppress the translation of target-mRNA,or directly degrade target-mRNA.MiR-29,a newly discovered miRNAs,is closely related with diabetes mellitus and its complications.MiR-29 involves in the pathophysiological processes of diabetes mellitus,such as involving in the insulin related signaling pathway.Meanwhile,miR-29 participates in the renal fibrosis and apoptosis of the retinal neurons,therefore plays important roles in the occurrence of diabetic nephropathy and diabetic retinopathy.
  • 摘要：糖尿病大血管病变是以动脉粥样硬化为主要病理特征的糖尿病慢性并发症之一.近年来,自身免疫因素在动脉粥样硬化发病中的作用越来越受到关注,多种自身抗体、自身抗原和免疫系统成分参与动脉粥样硬化的发生和发展.检测血液中几种自身抗原及其抗体,如氧化型低密度脂蛋白、p2糖蛋白Ⅰ、热休克蛋白的变化,可间接预测糖尿病患者动脉粥样硬化的发生、发展.对糖尿病大血管病变相关自身免疫更深入的研究,将为糖尿病大血管病变的早期诊断、监测和治疗开辟一条新的途径.%Diabetic macrovascular complication characterized by atherosclerosis is one of most common chronic complications of diabetes.Recently,the role of autoimmunity in the development of atherosclerosis is payed more and more attention.Many autoantigens,autoantibodies and immunologic factors are involved in the occurrence and development of atherosclerosis.Detecting some autoantigens and their antibodies,such as oxidized low-density lipoprotein,beta 2-glyeoprotein Ⅰ,heat shock proteins,could predict the development of atherosclerosis in diabetic patients.Along with more and more researches in autoimmunity of diabetic macrovascular complication,new pathways for early diagnosis,monitor and intervention of diabetic macrovascular complication would be found.

    国际内分泌代谢杂志的期刊信息

    • 曾用名：国外医学：内分泌学分册;国外医学.内分泌学分册;国外医学:内分泌学分册;国外医学(内分泌学分册)
    • 创刊时间：1981
    • 地区：CN
    • 语言：中文
    • 热门主题：中华医学会;天津医科大学
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    国际内分泌代谢杂志的获奖情况

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    • • 北大核心期刊（2011版）
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