Gluconeogenesis in Very Low Birth Weight Infants Receiving Total Parenteral Nutrition

摘要

Very low birth weight (VLBW) infants are dependent on total parenteral nutrition (TPN) to prevent hypogly- cemia and provide a sufficient energy intake. However, diminished tolerance for parenteral glucose delivered at high rates frequently provokes hyperglycemia. We hypothesized that when their glucose supply is reduced to prevent hyperglycemia, VLBW infants can maintain normoglycemia via gluconeogenesis from glycerol and amino acids. Twenty infants born at 27 ±0.2 (mean ±SE) gestational weeks and having a birth weight of 996±28 g, received lipids (1.6±0.1 mg.kg~-1. Min~-1), protein (2.2 ±0.1 mg.kg~-1. Min~-1), and glucose (3.1±0.1 mg. Kg~-1. Min~-1 [17.1±0.2 μmol. Kg~-1. Min~-1]) parenterally over a Period of 8-12 h on day 5.0±0.2 of life.