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首页> 外文期刊>Diabetes >Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors
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Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors

机译：2型糖尿病预防策略与冠心病遗传决定因素对心血管代谢危险因素的相互作用

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摘要

Coronary artery disease (CAD) is more frequent among individuals with dysglycemia. Preventive interventions for diabetes can improve cardiometabolic risk factors (CRFs), but it is unclear whether the benefits on CRFs are similar for individuals at different genetic risk for CAD. We built a 201 -variant polygenic risk score (PRS) for CAD and tested for interaction with diabetes prevention strategies on 1-year changes in CRFs in 2,658 Diabetes Prevention Program (DPP) participants. We also examined whether separate lifestyle behaviors interact with PRS and affect changes in CRFs in each intervention group. Participants in both the lifestyle and metformin interventions had greater improvement in the majority of recognized CRFs compared with placebo (P < 0.001) irrespective of CAD genetic risk (P_(interaction) > 0.05). We detected nominal significant interactions between PRS and dietary quality and physical activity on 1 -year change in BMI, fasting glucose, triglycerides, and HDL cholesterol in individuals randomized to metformin or placebo, but none of them achieved the multiple-testing correction for significance. This study confirms that diabetes preventive interventions improve CRFs regardless of CAD genetic risk and delivers hypothesis-generating data on the varying benefit of increasing physical activity and improving diet on intermediate cardiovascular risk factors depending on individual CAD genetic risk profile.
机译：血糖异常者中冠状动脉疾病（CAD）更为常见。糖尿病的预防性干预措施可以改善心脏代谢危险因素（CRF），但尚不清楚具有不同遗传风险的CAD患者对CRF的益处是否相似。我们为2658名糖尿病预防计划（DPP）参与者建立了201变量的CAD多基因风险评分（PRS），并测试了其与CRF的1年变化的糖尿病预防策略的相互作用。我们还检查了单独的生活方式行为是否与PRS相互作用并影响每个干预组中CRF的变化。生活方式和二甲双胍干预措施的参与者与安慰剂相比，在大多数公认的CRF中都有更大的改善（P <0.001），而与CAD遗传风险无关（P_（相互作用）> 0.05）。我们在随机分配给二甲双胍或安慰剂的个体中，在BMI，空腹血糖，甘油三酸酯和HDL胆固醇的1年变化中，检测到PRS与饮食质量和体育锻炼之间的名义上显着的相互作用，但他们都没有实现对显着性的多次测试校正。这项研究证实，无论CAD遗传风险如何，糖尿病预防干预措施都能改善CRF，并提供假说生成的数据，说明增加体育锻炼和改善饮食对中等心血管风险因素的不同益处，具体取决于各个CAD遗传风险状况。

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  • 来源
    《Diabetes》 |2020年第1期|112-120|共9页
  • 作者

    Jordi Merino; Kathleen A. Jablonski; Josep M. Mercader; Steven E. Kahn; Ling Chen; Maegan Harden; Linda M. Delahanty; Maria Rosario G. Araneta; Geoffrey A. Walford; Suzanne B.R. Jacobs; Uzoma N. Ibebuogu; Paul W. Franks; William C.Knowler; Jose C. Florez;

  • 作者单位

    Center for Genomic Medicine Massachusetts General Hospital Boston MA Diabetes Unit Massachusetts General Hospital Boston MA Programs in Metabolism and Medical and Population Genetics Eli and Edythe L. Broad Institute of MIT and Harvard Cambridge MA Department of Medicine Harvard Medical School Boston MA Research Unit on Lipids and Atherosclerosis CIBERDEM Institut d'lnvestigacio Sanitaria Pere Virgili Universitat Rovira i Virgili Reus Spain;

    The Biostatistics Center Department of Epidemiology and Biostatistics Milken Institute School of Public Health The George Washington University Rockville MD;

    Center for Genomic Medicine Massachusetts General Hospital Boston MA Diabetes Unit Massachusetts General Hospital Boston MA Programs in Metabolism and Medical and Population Genetics Eli and Edythe L. Broad Institute of MIT and Harvard Cambridge MA;

    Division of Metabolism Endocrinology and Nutrition VA Puget Sound Health Care System and University of Washington Seattle WA;

    Genomics Platform Eli and Edythe L. Broad Institute of MIT and Harvard Cambridge MA;

    Diabetes Unit Massachusetts General Hospital Boston MA Department of Medicine Harvard Medical School Boston MA;

    Department of Family Medicine and Public Health University of California San Diego La Jolla CA;

    Center for Genomic Medicine Massachusetts General Hospital Boston MA Diabetes Unit Massachusetts General Hospital Boston MA;

    Division of Cardiovascular Diseases Department of Medicine The University of Tennessee Health Science Center Memphis TN;

    Genetic & Molecular Epidemiology Unit Lund University Diabetes Centre Malmo Sweden Department of Public Health and Clinical Medicine Umea University Umea Sweden Department of Nutrition Harvard T.H. Chan School of Public Health Boston MA;

    Diabetes Epidemiology and Clinical Research Section National Institute of Diabetes and Digestive and Kidney Diseases Phoenix AZ;

    Center for Genomic Medicine Massachusetts General Hospital Boston MA Diabetes Unit Massachusetts General Hospital Boston MA Programs in Metabolism and Medical and Population Genetics Eli and Edythe L. Broad Institute of MIT and Harvard Cambridge MA Department of Medicine Harvard Medical School Boston MA;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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