Glucagon-Like Peptide?1 Receptor Agonists in Type?2 Diabetes Mellitus: Data from a Real-World Study in Spain

摘要

IntroductionThis study aimed to describe utilization patterns, persistence, resource utilization and costs in patients with type?2 diabetes mellitus initiating treatment with glucagon-like peptide?1 receptor agonists in routine clinical practice in Spain.MethodsThis retrospective study of medical records in the Big-Pac database identified adults starting treatment with once-weekly (QW) dulaglutide, exenatide-QW or once-daily liraglutide between 1 November 2015 and 30 June 2017. Patients were followed for up to 18?months from treatment initiation. Data on clinical characteristics of patients, treatment patterns, average daily dose and costs were obtained for the three cohorts. Persistence over the 18-month period was evaluated using Kaplan–Meier curves. All analyses were descriptive.ResultsA total of 1402 patients were included in this study (dulaglutide [ n =?492], exenatide-QW [ n =?438] or liraglutide [ n =?472]); 52.8% were men, and the mean (SD) age was 62 (11) years, glycated haemoglobin (HbA1c) was 8.1% (1.2) and body mass index was 35.5 (3.2) kg/m 2 at treatment initiation. Persistence at 18?months was 59.1% (95% confidence interval [CI] 54.8–63.4) for dulaglutide, 45.7% (95% CI 41.0–50.4) for exenatide-QW and 46.6% (95% CI 42.1–51.1) for liraglutide. The average (SD) dose was 1.2 (0.4) mg/week for dulaglutide, 1.9 (0.3) mg/week for exenatide-QW and 1.1 (0.3) mg/day for liraglutide. The average reduction in HbA1c levels at 1?year was ??0.68% for patients who initiated dulaglutide, ??0.54% for patients who initiated exenatide-QW and ??0.50% for patients who initiated liraglutide. The mean (SD) total annual health care costs were €4072 (1946) for dulaglutide, €4418 (2382) for exenatide-QW and €4382 (2389) for liraglutide.ConclusionResults suggest that patients who started treatment with dulaglutide had higher persistence over 18?months, presented lower HbA1c levels at 12?months and incurred lower annual total healthcare costs than patients who initiated exenatide-QW or liraglutide.