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Update on biology and management of mesothelioma

机译:Mesothelioma的生物学和管理更新

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Malignant pleural mesothelioma is an aggressive, incurable cancer that is usually caused by asbestos exposure several decades before symptoms arise. Despite widespread prohibition of asbestos production and supply, its incidence continues to increase. It is heterogeneous in its presentation and behaviour, and diagnosis can be notoriously difficult. Identification of actionable gene mutations has proven challenging and current treatment options are largely ineffective, with a median survival of 10–12?months. However, the past few years have witnessed major advances in our understanding of the biology and pathogenesis of mesothelioma. This has also revealed the limitations of existing diagnostic algorithms and identified new treatment targets. Recent clinical trials have re-examined the role of surgery, provided new options for the management of associated pleural effusions and heralded the addition of targeted therapies. The increasing complexity of mesothelioma management, along with a desperate need for further research, means that a multidisciplinary team framework is essential for the delivery of contemporary mesothelioma care. This review provides a synthesised overview of the current state of knowledge and an update on the latest research in the field.
机译:恶性胸膜间皮瘤是一种侵略性的癌症,通常是由于石棉暴露在症状出现之前几十年来引起的。尽管广泛禁止石棉生产和供应,但其发病率继续增加。它在其呈现和行为中是异质的,并且诊断可能是众所周知的。鉴定可行的基因突变已被证明挑战性,目前的治疗方案主要是无效的,中位存活率为10-12?月份。然而,过去几年目睹了我们对思皮瘤生物学和发病机制的理解的重大进展。这也揭示了现有诊断算法的局限性并确定了新的治疗目标。最近的临床试验重新检查了手术的作用,为管理相关的胸膜积液和预示着目标疗法提供了新的选择。间皮瘤管理的复杂性越来越复杂,以及绝望的进一步研究,这意味着多学科团队框架对于交付当代间皮瘤护理至关重要。本次审查提供了当前知识状态的合成概述以及关于该领域最新研究的更新。

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