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首页> 外文期刊>Frontiers in Medicine >Comorbidities of Patients With Idiopathic Pulmonary Fibrosis in Four Latin American Countries. Are There Differences by Country and Altitude?
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Comorbidities of Patients With Idiopathic Pulmonary Fibrosis in Four Latin American Countries. Are There Differences by Country and Altitude?

机译:四种拉丁美洲国家特发性肺纤维化患者的综合征。 国家和海拔地区是否存在差异?

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Background: Comorbidities in idiopathic pulmonary fibrosis (IPF) affect quality of life, symptoms, disease progression and survival. It is unknown what are the comorbidities in patients with IPF in Latin America (LA) and if there are differences between countries. Our objective was to compare IPF comorbidities in four countries and analyze possible differences by altitude. Methods: Patients with IPF according 2012 ATS/ERS/JRS/ALAT guidelines, from two cities with an altitude of ≥2,250 m: Mexico City (Mexico) and Bogotá (Colombia) and from three at sea level: Buenos Aires (Argentina) and Lima and Trujillo (Peru). Comorbidities and pulmonary function tests were taken from clinical records. Possible pulmonary hypertension (PH) was defined by findings in the transthoracic echocardiogram of systolic pulmonary arterial pressure (sPAP) 36 mmHg or indirect signs of PH in the absence of other causes of PH. Emphysema as the concomitant finding of IPF criteria on chest tomography plus emphysema in the upper lobes. ANOVA or Kruskal Wallis and χ 2 -tests were used for comparison. Results: Two hundred and seventy-six patients were included, 50 from Argentina, 86 from Colombia, 91 from Mexico and 49 from Peru. There prevalence of PH was higher in Colombia and Mexico ( p 0.001), systemic arterial hypertension in Argentina ( p 0.015), gastro-esophageal reflux and dyslipidemia in Colombia and Argentina ( p 0.001) and diabetes mellitus in Mexico ( p 0.007). Other comorbidities were obesity (28.4%), coronary artery disease (15.2%) and emphysema (14.9%), with no differences between countries. There was more PH in the altitude cities than those at sea level (51.7 vs. 15.3%, p 0.001). In patients from Bogotá and Mexico City, arterial oxygen pressure, saturation ( p 0.001) and carbon monoxide diffusing capacity ( p = 0.004) were significantly lower than in cities at sea level. Conclusions: In this study with a significant number of patients, we were able to describe and compare the comorbidities of IPF in four LA countries, which contributes to the epidemiological data of this disease in the region. The main results were the differences in comorbidities between the countries and more PH in the subjects residing in the cities of higher altitude, a finding that should be validated in future studies.
机译:背景:特发性肺纤维化(IPF)的合并症影响生活质量,症状,疾病进展和生存。它未知是什么是拉丁美洲(LA)患者的患者的合并症,如果国家之间存在差异。我们的目标是在四个国家进行比较IPF合并症,并通过海拔地区分析可能的差异。方法:IPF患者根据2012年的ATS / ERS ​​/ JRS / ALAT指南,来自两个城市,海拔≥2,250米:墨西哥城(墨西哥)和波哥大(哥伦比亚)和海上三级:布宜诺斯艾利斯(阿根廷)和利马和特鲁希略(秘鲁)。从临床记录中取出了合并症和肺功能测试。通过在没有其他pH的其他原因的情况下,通过细胞肺动脉压(SPAP)&GT; 36mmHg或pH值的间接迹象的调查结果定义了可能的肺动脉高压(pH)。呼气液作为胸部断层扫描加上IPF标准的伴随地位瓣膜上的IPF标准。 ANOVA或Kruskal Wallis和χ2-Test用于比较。结果:包括二百七十六名患者,50名来自阿根廷,哥伦比亚86名,来自墨西哥的91名,来自秘鲁49。在巨果和墨西哥(P <0.001),阿根廷的全身性动脉高血压(P& 0.015),含有食管反流和血脂血症在墨西哥的胃肠道(P <0.001)和糖尿病(P <0.015)中的全身动脉高血压和患有糖尿病(P <0.001)和墨西哥糖尿病的患者(P <0.007)。其他同血症是肥胖症(28.4%),冠状动脉疾病(15.2%)和肺气肿(14.9%),国家之间没有差异。高度城市的pH值高于海拔的pH(51.7 vs.15.3%,P <0.001)。在来自波哥大和墨西哥城的患者中,动脉氧气压力,饱和度(P <0.001)和一氧化碳扩散能力(P = 0.004)显着低于海平面的城市。结论:在这项研究中具有大量患者,我们能够描述并比较四个洛杉矶国家的IPF的合并,这有助于该地区该疾病的流行病学数据。主要结果是各国与居住在高海拔城市的主题中的合并和更多pH值的差异,这是应在未来研究中验证的一个发现。

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