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Survival outcome and prognostic factors in anaplastic oligodendroglioma: a single-institution study of 95 cases

机译:促进的少压雌雄瘤中的生存结果和预后因素:95例单机制研究

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The aim of this study was to evaluate prognostic factors including surgical, radiographic, and histopathologic analyses in anaplastic oligodendroglioma (AO) patients. We reviewed the electronic records of 95 patients who underwent surgery and were diagnosed with AO for 20?years. The primary endpoints were progression-free survival (PFS) and overall survival (OS). Univariate and multivariable analyses included clinical, histopathological, and radiographic prognostic factors. Subgroup analysis was performed in isocitrate dehydrogenase (IDH1/2)-mutant and 1p/19q-codeleted patients. The median PFS and OS were 24.7?months and 50.8?months, respectively. The 1-, 3-, 5-, and 10-year PFS were 75.8%, 42.9%, 32.4%, and 16.4%, respectively. Furthermore, the 1-, 3-, 5-, and 10-year OS were 98.9%, 76.9%, 42.9%, and 29.7%, respectively. The median PFS and OS of the IDH1/2-mutant and 1p/19q-codeleted patients were 54.2 and 57.8?months, respectively. In univariate analyses, young age, frontal lobe, weak enhancement, gross total resection (GTR), low Ki-67 index, 1p/19q codeletion, and IDH1/2 mutations were associated with a favorable outcome. In multivariable analyses, IDH1/2 mutation was related to better PFS and OS. In subgroup analysis, GTR was associated with favorable outcomes.
机译:本研究的目的是评估预后因素,包括外科,射线摄影和组织病理学分析,在促进的少突卵瘤(AO)患者中。我们审查了95名接受手术的患者的电子记录,并被诊断为20岁的疗程。主要终点是无进展的存活(PFS)和总存活(OS)。单变量和多变量分析包括临床,组织病理学和射线照相预后因素。在异柠檬酸脱氢酶(IDH1 / 2) - 级别和1P / 19Q-CODELTED患者中进行亚组分析。中位数PFS和OS分别为24.7个月和50.8个月?几个月。 1-,3-,5-和10年的PFS分别为75.8%,42.9%,32.4%和16.4%。此外,1-,3-,5-和10年的OS分别为98.9%,76.9%,42.9%和29.7%。 IDH1 / 2-突变体和1P / 19Q-CODELTED患者的中位数和OS分别为54.2和57.8?数月。在单变量分析中,幼年龄,额叶,弱增强,总切除总体(GTR),低KI-67指数,1P / 19Q Comethion和IDH1 / 2突变与有利的结果有关。在多变量分析中,IDH1 / 2突变与更好的PFS和OS有关。在亚组分析中,GTR与有利的结果有关。

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