Urodynamic prognostic factors for large post-void residual urine volume after intravesical injection of onabotulinumtoxinA for overactive bladder

摘要

The aim of this study was to identify factors predicting large post-void residual (PVR) (defined as ≥200?mL), an important unsolved problem, after an intravesical injection of onabotulinumtoxinA in patients with overactive bladder syndrome. The data showed that 133 of 290 patients had a large PVR after treatment. Multivariate analysis found that the baseline 3-day daytime frequency episodes and voiding efficiency were independent predictors for postoperative large PVR. A receiver operating characteristic (ROC) curve analysis showed the following optimum cut-off values: (1) 3-day daytime frequency episodes?=?25, which has a ROC area of 0.72; and (2) voiding efficiency?=?89%, which has a ROC area being 0.66. The predicted logit transformation of probability of large PVR, logit(p), for a given 3-day daytime frequency episodes (a) and voiding efficiency (b%) can be denoted by logit(p)?=??5.18?+?0.07?×?a?+?0.04?×?b, with a cutoff value of logit(p)?=?0.34 and a ROC area of 0.79. The median value of the persistent large PVR interval was 5 months. In conclusion, low 3-day daytime frequency episodes (25) and low voiding efficiency (89%) are associated with large PVR. Besides, logit(p) 0.34 can be used to predict large PVR for its higher ROC area.