Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines

摘要

In the present research, a series of 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5,286-Bis aryl 1%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>6-Bis aryl 1,2,4-triazines 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5a~285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5f were synthesized by condensation of various benzils 4a~4f with aminoguanidine bicarbonate and were screened in vivo, for their anticonvulsant and neurotoxicity studies. Compounds 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5a, 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5b and 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5d were found to be potent molecules of this series, when compared with the reference drugs phenytoin sodium, diazepam and lamotrigine. The structures of these compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopic data.