Synthesis and anticonvulsant activity of some potent 56-bis aryl 124-triazines

摘要

In the present research, a series of 5,6-bis aryl 1,2,4-triazines >5a~>5f were synthesized by condensation of various benzils >4a~>4f with aminoguanidine bicarbonate and were screened in vivo, for their anticonvulsant and neurotoxicity studies. Compounds >5a, >5b and >5d were found to be potent molecules of this series, when compared with the reference drugs phenytoin sodium, diazepam and lamotrigine. The structures of these compounds were established by IR, ¹H NMR, ¹³C NMR and mass spectroscopic data.