Ameliorative Effects of Allium cepa and Allium sativum on Diabetes Mellitus and Dyslipidemia in Alloxan-induced Diabetic Rattus novergicus

摘要

Background and Objectives: Dyslipidemia is a common complication of diabetes mellitus with a pathological link to cardiovascular disease s. The use of synthetic chemicals in therapy leads to unexpected toxic effects, hence, the need for the use of natural plants as therapeutic agents. The study was designed to investigate the natural therapeutic agents such as; Allium cepa and Allium sativum in the treatment of diabetes mellitus and dyslipidemia. Materials and Methods: A total of 68 rats were divided into 4 groups of 17 rats each. Group1 served as control and were fed with rat feed and distilled water only. Diabetes mellitus was induced in 51 rats by administering intraperitoneally 150 mg of alloxan per kg body weight (bw) of the rats. Diabetic rats were divided into groups II, III and IV which were fed with rat feed and distilled water. In addition, the three groups were fed with 1.00, 1.50 and 2.00 mg kgsup?/supsup1/sup between aqueous extract of Allium cepa , respectively. The feeding procedures for group II, III and IV were repeated with aqueous extract of Allium sativum replacing Allium cepa . Animals were fed for 4 weeks. Blood samples were collected from ocular median-cantus vein of the rats. Plasma was separated for analysis. Blood glucose and lipid profile s of the rats were determined by standard laboratory methods. Results: Allium cepa and Allium sativum aqueous extracts significantly (p0.05) lowered the blood glucose , triacylglycerol, total cholesterol and low-density lipoprotein and significantly (p0.05) increased the high-density lipoprotein when compared with the control. Conclusion: Aqueous extracts of Allium cepa and Allium sativum show ameliorative effects on diabetes.