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Application of exosomes as liquid biopsy in clinical diagnosis

机译:外来体在临床诊断中的液体活检应用

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Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small extracellular vesicles with sizes between 30–150?nm. They are secreted by multivesicular bodies through exocytosis in live cells and can participate in intercellular communication due to their contents, including nucleic acids, proteins, and lipids. Herein, we investigate publication frequencies on exosomes over the past 10 years, and review recent clinical studies on liquid biopsy of exosomes in the fields of oncology, pregnancy disorders, cardiovascular diseases, and organ transplantation. We also describe the advantages of exosomes as an effective liquid biopsy tool and the progression of exosome extraction methods. Finally, we depict the commercial development of exosome research and discuss the future role of exosomes in liquid biopsy.
机译:液体活检是指循环肿瘤细胞,细胞内囊泡,核酸等生物流体的采样和分子分子分析。外泌体是小细胞外囊,尺寸在30-150℃之间。它们通过活细胞中的外尿精分泌,并且可以通过它们的内容物参与细胞间通信,包括核酸,蛋白质和脂质。在此,我们在过去10年中调查外来运动的出版频率,并审查肿瘤学,妊娠障碍,心血管疾病和器官移植领域外来液检查的最近临床研究。我们还描述了外来物作为一种有效的液体活检工具的优点以及外出提取方法的进展。最后,我们描绘了外科研究的商业发展,并讨论外来体在液体活检中的未来作用。

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