A Complex Relationship: Dietary Folate, Arsenic Metabolism, and Insulin Resistance in Mice

摘要

More than 144 million people worldwide are believed to drinkwater with inorganic arsenic (iAs) concentrations exceedingthe World Health Organization guideline of 10 ppb.1 Consumption of drinking water with high levels of iAs—more than100 ppb—has been associated with numerous adverse healthoutcomes in humans,2 including diabetes.3,4 A recent study5published in Environmental Health Perspectives highlights thepotential complexity of the iAs–diabetes relationship: Investigators reported that, under some conditions, dietary folatemay modify both iAs metabolism and diabetes-related outcomes in mice.