Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D2

摘要

Syntheses of analogue compounds of cortistatin A ( 1 ), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D₂. The incidental preparation of a new analogue having CD- cis -fused skeleton and its biological evaluation revealed the importance of the CD- trans -fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs).