Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease

摘要

. Older age (r?=?-0.46), male sex (r?=?-0.34), lower eGFR (r?=?0.27), lower serum-corrected calcium (r?=?0.27), higher PTH (r?=?-0.36), and higher ALP level (r?=?-0.20) were identified as determinants of lower number of RTE. In contrast, serum concentrations of FGF23 and phosphorus were not correlated with RTE. Multivariate non-linear regression analysis indicated a negative association between serum PTH and log-transformed RTE (P?=?0.030, P for non-linearity?=?0.124). However, the serum levels of FGF23 and ALP were not associated with RTE. In patients with CKD, serum PTH concentrations were related to thymic atrophy which contributes to immune abnormality.