RELATIONSHIP BETWEEN ULTRAVIOLET SENSITIVITY AND ABILITY TO PROPAGATE ULTRAVIOLET-IRRADIATED BACTERIOPHAGE

摘要

Hill, Ruth F. (Columbia University, New York, N.Y.). Relationship between ultraviolet sensitivity and ability to propagate ultraviolet-irradiated bacteriophage. J. Bacteriol. >88:1283–1287. 1964.—Mutants with a reduced ability to propagate ultraviolet-damaged bacteriophage T₁ were isolated from Escherichia coli strain B/r. The change in this ability varied from a slight to a very marked loss; the greater the loss, the greater was the ultraviolet sensitivity of the mutant. Reduced ability to propagate irradiated T₁ appears to be the more sensitive index of genetic change, because in one mutant there was no significant reduction in ultraviolet resistance. In a converse study, second-step mutants with an increased ultraviolet resistance were obtained from a mutant of E. coli B. This mutant is both unable to propagate irradiated T₁ and very ultraviolet-sensitive. The increased ultraviolet resistance of the second-step mutants was not accompanied by an increased ability to propagate irradiated T₁.