Risky Decision-Making and the Intensity of Opioid Drug Dependency in Early Phase of Methadone Maintenance Protocol

摘要

Several studies show positive effect of MMT on decision-making in substance dependents, but severity of the disorder has been ignored by most of them. This study used Iowa Gambling Task(IGT) to find correlation between severity of the disorders in early phase of MMT and risky decision-making inthree groups of subjects (mild, sever, control). The study shows no significant difference among groups in risky decision-making,which might be related to the effect of opioid on cognitive functions independent of the severity of the disorder, and stabilization in MMT can repair deficit in decision making shortly during the early phase.