Synthesis, Characterization and Biological Screening of New 4-Thiazolidinones having Potentially Active Tetrazole Moiety

摘要

A series of new 4- Thiazolidinones (II) have been synthesized by the reaction of 2-Amino-4-substituted phenyl- 1-(2H)-Tetrazole(s) with substituted Phenyl isothiocynate(s) to generate N’-(4-substitutedphenyl)-N”-1- [(3’-substituted Phenyl)-6-tetrazolyl]-Thiocarbamide(s) (I). Which was further reacted with mono chloro acetic acid in presence of anhydrous sodium acetate and acetic acid to form new 4-Thiazolidinone(s) (II). The synthesized compounds have been confirmed by their elemental and spectral analysis. The synthesized 4- Thiazolidinones have been screened against E coli for their antibacterial activity. Some of the compounds are shown good antibacterial activity..