MiR‐365b‐3p, down‐regulated in retinoblastoma, regulates cell cycle progression and apoptosis of human retinoblastoma cells by targeting PAX6

摘要

PAX6contributestothedevelopmentandprogressionofretinoblastoma(RB),butthemolecularmechanismunderlyingtheregulationofPAX6expressionisunclear.HerewefoundthatmicroRNA‐365b‐3p(miR‐365b‐3p)isdownregulatedinhumanRBtissues.EctopicexpressionofmiR‐365b‐3psignificantlyattenuatescellgrowth,inducescellcyclearrestinG1phaseandcellapoptosisthroughinhibitingtheexpressionofPAX6bydirectlybindingits3′untranslatedregions.Furthermore,overexpressionofmiR‐365b‐3pupregulatesp21andp27butdownregulatescdc2andCyclinD1proteinlevels.ElucidatingtheregulatorymechanismofPAX6bymicroRNAsmaygivenewcluestothetherapyagainstRB...