B cell translocation gene, a direct target of miR‐142‐5p, inhibits vascular smooth muscle cell proliferation by down‐regulating cell cycle progression

摘要

Vascularsmoothmusclecell(VSMC)proliferationplaysakeyroleinneointimalhyperplasiaandrestenosis.HerewereporttheroleofthemicroRNAmiR‐142‐5panditsdownstreamtargetgenesontheproliferationofculturedVSMCs.miR‐142‐5ppromotedVSMCproliferationbydown‐regulatingBcelltranslocationgene3(BTG3).WefoundthatBTG3inhibitedtheexpressionofcellcycleregulatorygenesandcellgrowth.Asshownbyluciferasereporterassay,miR‐142‐5pbounddirectlytothe3′‐untranslatedregionofBTG3.OverexpressionofmiR‐142‐5pinducedexpressionofcellcycleregulatorygenes.Thus,BTG3,anovel,directtargetofmiR‐142‐5p,negativelyregulatesVSMCproliferation...