In vivo expression of podocyte slit diaphragm-associated proteins in nephrotic patients with NPHS2 mutation

摘要

In vivo expression of podocyte slit diaphragm-associated proteins in nephrotic patients with NPHS2 mutation.BackgroundMutations in NPHS2, encoding podocin, are a prevalent cause of autosomal-recessive steroid-resistant nephrotic syndrome (SRNS). Podocin is a protein associated with the slit diaphragm that interacts with nephrin and CD2-associated protein (CD2AP) within lipid rafts.