Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis

摘要

Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis.BackgroundMicroarray technology is a powerful tool that can probe the molecular pathogenesis of renal injury. In this present study microarray analysis was used to monitor serial changes in the renal transcriptome of a rat model of mesangial proliferative glomerulonephritis. Administration of anti-Thy1 antibody results in phases of acute mesangial injury (day 2), cell proliferation (day 5), matrix expansion (days 5 and 7), and subsequent healing (day 14).