235 Negatively-charged sulfonate group in linker improves potency of antibody–maytansinoid conjugates against multidrug-resistant cancer cells

Y. Kovtun; G. Jones; C. Audette; M. Mayo; B. Leece; R. Zhao; L. Clancy; X. Sun; R. Chari; R. Singh

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235 Negatively-charged sulfonate group in linker improves potency of antibody–maytansinoid conjugates against multidrug-resistant cancer cells

机译：235接头中带负电荷的磺酸盐基团提高了抗体-美登木素生物碱偶联物对多药耐药癌细胞的效力

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《European Journal of Cancer Supplements》 |2010年第7期|共2页
作者
Y. Kovtun; G. Jones; C. Audette; M. Mayo; B. Leece; R. Zhao; L. Clancy; X. Sun; R. Chari; R. Singh;
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中图分类肿瘤学;
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1. Site-Specific Trastuzumab Maytansinoid Antibody-Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering [J] . Thomas H. Pillow, Janet Tien, Kathryn L. Parsons-Reponte, Journal of Medicinal Chemistry . 2014,第19期

机译：特定部位的曲妥珠单抗美登木素生物碱抗体-药物通过接头和抗体工程结合起来具有改善的治疗活性
2. Tumor Delivery and In Vivo Processing of Disulfide-Linked and Thioether-Linked Antibody-Maytansinoid Conjugates [J] . Hans K. Erickson, Wayne C. Widdison, Michele F. Mayo Bioconjugate Chemistry . 2010,第1期

机译：二硫键和硫醚键抗体-美登木素生物碱偶联物的肿瘤传递和体内加工
3. Tumor Delivery and In Vivo Processing of Disulfide-Linked and Thioether-Linked Antibody−Maytansinoid Conjugates [J] . Hans K. Erickson Wayne C. Widdison Michele F. Mayo Kathleen Whiteman Charlene Audette Sharon D. Wilhelm and Rajeeva Singh American Chemical Society . 2009,第1期

机译：二硫键和硫醚键抗体-美登木素生物碱偶联物的肿瘤传递和体内加工
4. Evaluation of the Relationship between Maytansinoid-to-Antibody Ratio and Maytansinoid Distribution Profile in Antibody-Maytansinoid Conjugates [C] . Megan Ellis, Lintao Wang, Alexandru C. Lazar, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：评估抗体 - Maytansinoid缀合物中Maytansinoid-antidody比和Maytansinoid分布分布的关系
5. Improving Antibody-Drug Conjugate Tumor Distribution and Efficacy Using Single-Cell Imaging and Multiscale Modeling [D] . Cilliers, Cornelius 2018

机译：使用单细胞成像和多尺度建模改善抗体药物结合的肿瘤分布和功效
6. Erratum to: Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer [O] . Liang Feng, Hang-Ping Yao, Sharad Sharma, 2016

机译：勘误：抗体-美登木素生物碱偶联物的生物学评估作为RON靶向药物递送治疗非小细胞肺癌的策略
7. Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer [O] . Liang Feng, Hang-Ping Yao, Sharad Sharma, 2016

机译：抗体-美登木素生物碱偶联物的生物学评估作为RON靶向药物递送治疗非小细胞肺癌的策略

235 Negatively-charged sulfonate group in linker improves potency of antibody–maytansinoid conjugates against multidrug-resistant cancer cells

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