method of targeting specific cell populations by employing cell linker maytansinoid conjugates linked via a non-cleavable binder, said conjugates, and methods of preparing said conjugates

摘要

"A method of targeting specific cell populations by employing non-cleavable ligand-linked maytansinoid conjugates, said conjugates, and methods of preparing said conjugates." The present invention relates to a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population, with a cell-binding agent maytansinoid conjugate. that one or more maytansinoids is covalently attached to the cell binding agent via a non-cleavable binder and the cell binding agent binds to cells of the selected cell population.