method of targeting specific cell populations by employing non-cleavable ligand-linked maytansinoid conjugates, said conjugates, and methods of preparing said conjugates

摘要

"METHOD OF TARGETING CELL POPULATIONS SPECIFICALLY USING MAYTANSINOID ASSEMBLIES OF CELLULAR BINDING CONNECTED THROUGH A NON-CLIVABLE BINDING, AND REFERRED TO THE PREPARATIONS OF PREPARED REFERENCES. The present invention relates to a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population, with a cell-binding agent maytansinoid conjugate. that one or more maytansinoids is covalently attached to the cell binding agent via a non-cleavable ligand and the cell binding agent binds to cells of the selected cell population.