Next generation sequencing targeting drug resistance conferring genes in rapid detection of Multi-drug resistant tuberculosis

摘要

Background: Tuberculosis (TB) is one of the public health crisis caused by Mycobacterium tuberculosis complex. The emergence of multi-drug resistant TB (MDR-TB) and extensively drug resistant TB (XDR-TB) has affected disease management. There is a need for rapid, accurate diagnosis of TB and initiation of appropriate treatment. We have performed whole genome analysis for evaluation of drug resistance conferring mutations early in the clinical isolates from patients who fail Anti-tubercular treatment (ATT).