Prevalence of Panton-Valentine leukocidin genes among carriage and invasive Staphylococcus aureus isolates in Malaysia

摘要

Staphylococcus aureus nasal colonization is common among humans, and causality between carriage and invasive diseases has been substantiated.1 The pathogenicity of S. aureus is determined by a variety of bacterial cell wall surface components and exoproteins. Panton–Valentine leukocidin (PVL), one of these pathogenic determinants, is a bicomponent cytotoxin encoded by the pvl genes luk-S-PV and luk-F-PV. PVL destroys leukocytes by creating pores in the mitochondrial membrane.2 The PVL genes are predominantly associated with S.Keywords: PVL, Malaysia, MRSA, Nasal carriage