Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors

Mark Roberts; Steven Chatfield; Derek Pickard; Jingli Li; Andrew Bacon

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Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors

机译：鼠伤寒沙门氏菌鼠伤寒杆菌aroA aroD和aroA htrA突变体作为活载体的能力比较

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We compared the ability of Salmonella enterica serovar Typhimurium SL1344 aroA aroD (BRD509) and aroA htrA (BRD807) mutants to act as live vectors for delivery of fragment C of tetanus toxin (FrgC). FrgC was expressed in these strains from either pTETnir15 or pTEThtrA1. BRD509FrgC+ strains elicited ～2-log-higher serum anti-FrgC antibody titers than BRD807FrgC+ strains. All mice immunized with BRD807pTEThtrA1, BRD509pTEThtrA1, and BRD509pTETnir15 (but not BRD807pTETnir15) were protected against tetanus.

机译：我们比较了沙门氏菌血清鼠伤寒沙门氏菌SL1344 aroA （BRD509）和 aroA htrA （BRD807）突变体作为活载体传递的能力破伤风毒素（FrgC）片段C的片段。在来自pTETnir15或pTEThtrA1的这些菌株中表达了FrgC。与BRD807FrgC + 菌株相比，BRD509FrgC + 菌株产生的血清抗FrgC抗体滴度高约2个对数。 BRD807pTEThtrA1，BRD509pTEThtrA1和BRD509pTETnir15（但不是BRD807pTETnir15）免疫的所有小鼠均免受破伤风的侵害。 展开▼

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《Infection and immunity》 |2000年第10期|共3页

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Mark Roberts; Steven Chatfield; Derek Pickard; Jingli Li; Andrew Bacon;
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中图分类医学免疫学;

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1. Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors [J] . Mark Roberts, Steven Chatfield, Derek Pickard, Infection and immunity . 2000,第10期

机译：鼠伤寒沙门氏菌鼠伤寒杆菌aroA aroD和aroA htrA突变体作为活载体的能力比较

2. Salmonella typhimurium aroA, htrA, and aroD htrA mutants cause progressive infections in athymic (nuu) BALB/c mice. [J] . K Sinha, P Mastroeni, J Harrison, Infection and immunity . 1997,第4期

机译：鼠伤寒沙门氏菌aroA，htrA和aroD htrA突变体在无胸腺（nu / nu）BALB / c小鼠中引起进行性感染。

3. Comparative analysis of protein profiles of wild virulent (E156) and aroA-htrA double deletion mutant vaccine strain (S30) of Salmonella enterica subsp enterica serovar Abortusequi under in vivo and in vitro growth conditions [J] . Chandra Mudit, Singh B. R., Srivastava S. K., Indian Journal of Experimental Biology . 2008,第9期

机译：体内和体外生长条件下肠炎沙门氏菌亚种肠型血清型Abortusequi野生毒力（E156）和aroA-htrA双缺失突变疫苗株（S30）蛋白质谱的比较分析

4. A comparison of sampling methods for Salmonella enterica serovar Typhimurium [C] . Will Fombelle, Carrie Pollard, Noel Garbes, Annual^Meeting of the American Association^of^Swine^Veterinarians. . 2014

机译：Salmonella肠道血吸虫伤寒沙门氏菌采样方法的比较

5. Comparison of the genetics and in-vitro virulence of Salmonella enterica serovar Typhimurium isolated from California dairy cattle and humans. [D] . Adaska, John Michael. 2005

机译：从加利福尼亚奶牛和人类分离的肠炎沙门氏菌鼠伤寒沙门氏菌的遗传学和体外毒力比较。

6. Note: Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors [O] . Mark Roberts, Steven Chatfield, Derek Pickard, 2000

机译：注意：沙门氏菌鼠伤寒沙门氏菌aroA aroD和aroa htrA突变体作为活载体的能力比较

7. Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors [O] . Roberts, Mark, Chatfield, Steven, Pickard, Derek, 2000

机译：鼠伤寒沙门氏菌鼠伤寒杆菌aroA aroD和aroA htrA突变体作为活载体的能力比较

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6. 表达EtMIC3及EtAMA1蛋白重组减毒鼠伤寒沙门氏菌活载体疫苗株的构建 [C] . 吕俊峰 ,张怡聪 ,李宏梅 . 中国畜牧兽医学会家畜寄生虫学分会第七次代表大会暨第十二次学术研讨会 . 2013

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1. 鼠伤寒沙门菌aroA和luxS双基因缺失株及其制备的弱毒疫苗 [P] . 中国专利： CN107034160B . 2020.09.11

2. 鼠伤寒沙门菌aroA和luxS双基因缺失株及其制备的弱毒疫苗 [P] . 中国专利： CN107034160A . 2017-08-11

3. VACCINE VECTOR COMPRISING ATTENUATED SALMONELLA ENTERICA TYPHIMURIUM WHICH ARE MUTANTS FOR THE GENE FIS, VACCINE COMPRISING SAID VECTOR AND USE OF SAID VECTOR [P] . 外国专利： WO2016090440A1 . 2016-06-16

机译：包含减弱的基因 FIS 的沙门氏菌肠炎沙门氏菌疫苗，包含所述矢量的疫苗和使用所述矢量的疫苗

4. Vaccine vector comprising salmonella enterica typhimurium attenuated mutants for the fis gene, vaccine comprising said vector and use of said vector [P] . 外国专利： BR102014030638A2 . 2016-09-20

机译：包含针对fis基因的肠炎沙门氏菌减毒突变株的疫苗载体，包含所述载体的疫苗和所述载体的用途

5. Use of Salmonella enterica ssp. enterica serovar Typhimurium antigens for serological differentiation of infected and vaccinated pigs [P] . 外国专利： CZ20131048A3 . 2015-04-22

机译：使用沙门氏菌小肠沙门氏菌。肠炎血清鼠伤寒抗原用于感染猪和疫苗接种猪的血清学区分

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Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors

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