首页> 美国卫生研究院文献>Infection and Immunity >Note: Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors
【2h】

Note: Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors

机译:注意:沙门氏菌鼠伤寒沙门氏菌aroA aroD和aroa htrA突变体作为活载体的能力比较

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

We compared the ability of Salmonella enterica serovar Typhimurium SL1344 aroA aroD (BRD509) and aroA htrA (BRD807) mutants to act as live vectors for delivery of fragment C of tetanus toxin (FrgC). FrgC was expressed in these strains from either pTETnir15 or pTEThtrA1. BRD509FrgC+ strains elicited ∼2-log-higher serum anti-FrgC antibody titers than BRD807FrgC+ strains. All mice immunized with BRD807pTEThtrA1, BRD509pTEThtrA1, and BRD509pTETnir15 (but not BRD807pTETnir15) were protected against tetanus.
机译:我们比较了沙门氏菌血清型鼠伤寒沙门氏菌SL1344 aroA aroD(BRD509)和aroA htrA(BRD807)突变体作为活载体传递破伤风毒素(FrgC)片段C的能力。在来自pTETnir15或pTEThtrA1的这些菌株中表达了FrgC。与BRD807FrgC + 菌株相比,BRD509FrgC + 菌株产生的血清抗FrgC抗体滴度高约2个对数。 BRD807pTEThtrA1,BRD509pTEThtrA1和BRD509pTETnir15(而非BRD807pTETnir15)免疫的所有小鼠均免受破伤风的侵害。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号