Enantioseparation of Racemic 1,1'-Binaphthyl-2,2'-diamine by Preparative Liquid Chromatography

摘要

The same kind of chiral stationary phase with a commercialized chiral column was used to make preparative chiral columns and was applied to resolve racemic N-acetyl-1-naphthylethylamide (3) by preparative liquid chromatography. An improved chromatographic condition to resolve racemic 3 on the CSP was examined by changing flow rate and kind of the mobile phase and the sample injection volume. The optimized separation conditions were applied to resolve racemic 1,1`-binaphthyl-2,2`-diamine (4).