Enhanced wound healing by topical administration of d-limonene in alloxan induced diabetic mice through reduction of pro-inflammatory markers and chemokine expression

摘要

Delayed wound healing constitutes one of the most seriousdiabetes-associated complications. Diabetes can hinderthe normal wound healing process by inducing longterminflammation which can lead to delayed maturationof granulation tissues, reduced wound parallel tensionand inhibition of angiogenesis [1]. D-limonene, one ofthe major constituent in citrus essential oils is consideredto have antioxidant, hypoglycemic and anti-inflammatoryactivities [2].